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US 2002/0160458 A1Published application
Method for the production of FVII
OwnerHelle Woldike, Finn Wiberg +1inventors
InventorsHelle Woldike, Finn Wiberg, Lars Soegaard Nielsen
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Abstract
Disclosed is a method for high efficiency release of recombinant proteins in eukaryotic cells and more specifically, for enhancing the secretion of Factor VII by co-expression of kex2 endoprotease with FVII in cells of mammalian origin.
Claims10
A method for producing Factor VII comprising (a) cultivation of a mammalian cell line comprising a DNA sequence encoding a yeast endoprotease or a derivative thereof and a DNA sequence encoding FVII in a suitable culture medium;
- and (b) isolation of Factor VII from the medium.
Dependencies are inferred from the claim text.