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AssigneePresident and Fellows of Harvard College
InventorsLaurie H. Glimcher, John Douhan III
Estimating the term…
Isolated nucleic acid molecules encoding human c-Maf, and isolated c-Maf proteins, are provided. The invention further provides antisense nucleic acid molecules. recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a human c-Maf transgene. The invention further provides human c-Maf fusion proteins and anti-human c-Maf antibodies. Methods of using the human c-maf compositions of the invention are also disclosed, including methods for detecting human c-Maf activity in a biological sample, methods of modulating human c-Maf activity in a cell, and methods for identifying agents that modulate the activity of human c-Maf.
An isolated nucleic acid molecule comprising a nucleotide sequence encoding human c-Maf.
An isolated nucleic acid molecule comprising the nucleotide sequence of the coding region of the NheI/XbaI insert of plasmid pHu-c-Maf (ATCC Accession No. 98671).
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
An isolated human c-Maf protein.
An isolated protein comprising the amino acid sequence of SEQ ID NO:
A fusion protein comprising a human c-Maf protein operatively linked to a polypeptide other than human c-Maf.
Antibodies that specifically bind human c-Maf protein.
A nonhuman transgenic animal that contains cells carrying a transgene encoding a human c-Maf protein.
A method for detecting the presence of human c-Maf in a biological sample comprising contacting the biological sample with an agent capable of detecting an indicator of human c-Maf activity such that the presence of human c-Maf is detected in the biological sample.
A method for modulating human c-Maf activity in a cell comprising contacting the cell with an agent that modulates human c-Maf activity such that human c-Maf activity in the cell is modulated.
A method for identifying a compound that modulates the activity of a human c-Maf protein, comprising
Dependencies are inferred from the claim text.