Chromogenic substrate to detect urine adulteration
AssigneeApplied Biotech, Inc.
InventorsLakshmi Anne, Weixing Luo, Ker-kong Tung
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Abstract
A device and method to detect oxidant adulterants added to a sample to prevent detection of tetrahydrocannabinol and/or tetrahydrocannabinol metabolites. The device and method detect popularly available adulterants such as chromate and nitrite through their reaction with a chromogenic substrate for a peroxidase enzyme. The substrate may be applied to a pad. A change in color in the presence of the oxidant may be detected directly or indirectly. The device and method may be used to detect the presence of any oxidant adulterant and is not specific for only one or a few adulterants added to a urine sample submitted for drug testing.
Claims17
A method for detecting an oxidant chemical added to adulterate a biological sample comprising reacting said sample with a chromogenic substrate for a peroxidase and thereafter monitoring said sample for production of said chromogen indicating the presence of said oxidant chemical.
A device to detect adulteration of a biological sample provided by an individual with a chemical oxidant that prevents detection of marijuana use by said individual comprising a sample-contacting pad containing a substrate that forms a chromogen in the presence of said oxidant.
A method to detect adulteration of a urine sample with an oxidant chemical to prevent a positive drug test of said sample comprising adding a chromogenic peroxidase substrate to said adulterated sample and monitoring said sample for an increased absorbance indicating formation of said chromogen in the presence of said oxidant.
Dependencies are inferred from the claim text.