Method for identifying compounds which positively influence inflammatory conditions
OwnerBirgit Jung, Stefan Mueller +1inventors
InventorsBirgit Jung, Stefan Mueller, Norbert Kraut
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Abstract
The present invention relates to kinases involved in inflammatory processes and the modulation of the function of such kinases in order to positively influence inflammatory diseases.
Claims54
A method for determining whether a substance is an activator or an inhibitor of a function of a protein comprising:
- (a) contacting the protein with a substance to be tested, wherein the protein is a DHAM-kinase;
- and (b) measuring whether the function is inhibited or activated.
A method for determining whether a substance is an activator or an inhibitor of a function of a protein comprising:
- (a) contacting the protein with a substance to be tested, wherein the protein is a variant, mutant or fragment of a DHAM-kinase having a function of the corresponding DHAM-kinase;
- and (b) measuring whether the function is inhibited or activated.
The method according to claim I wherein the inhibition or activation of the desired function is measured directly.
A method for determining an expression level of a DHAM-kinase comprising:
- (a) determining the level of the DHAM-kinase expressed in a hyperactivated macrophage;
- (b) determining the level of the DHAM-kinase expressed in a non-hyperactivated macrophage;
- and (c) comparing the level of the DHAM-kinase expressed in step (a) to the level of the DHAM-kinase expressed in step (b), wherein a difference in levels indicates a differentially expressed DHAM-kinase.
A method for diagnosing or monitoring a chronic inflammatory airway disease comprising:
- (a) determining the level of a DHAM-kinase expressed in a hyperactivated macrophage;
- (b) determining the level of the DHAM-kinase expressed in a non-hyperactivated macrophage;
- and (c) comparing the level of the DHAM-kinase expressed in step (a) to the level of the DHAM-kinase expressed in step (b), wherein a difference in levels indicates a differentially expressed DHAM-kinase.
A substance determined to be an activator or an inhibitor of a DHAM-kinase.
A substance for the treatment of a disease wherein the substance is an activator or an inhibitor of a DHAM-kinase.
A pharmaceutical composition comprising at least one substance which is an activator or an inhibitor of a DHAM-kinase;
- and a pharmaceutical carrier.
A method for treating a chronic inflammatory airway disease comprising:
- administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising at least one substance determined to be an activator or an inhibitor of a DHAM-kinase.
A method for selectively modulating a DHAM-kinase in a macrophage, comprising administering a substance determined to be an activator or an inhibitor of a DHAM-kinase.
Dependencies are inferred from the claim text.