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OwnerLuc Levesque, Jean Raymond +2inventors
InventorsLuc Levesque, Jean Raymond, Guy Leclerc, Francis Gauthier
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The invention relates to a method for the sustained endovascular treatment of aneurysms, such as intracranial or for closing any body lumen, such as vascular lumen or other using an occlusion device for the local delivery of biologically active DNA therapeutic molecules. The invention also relates to a method for a rapid preparation of the artificial occlusion device to be coated shortly before or during the clinical procedure. A subsequent step in the method of treatment involves introducing at an aneurysm site or inside a vessel a slow-releasing, biologically active DNA molecule-leaching device. The device releases a biologically active DNA molecule at the aneurysm site for stimulating neointima formation and for increasing neointima thickness. The neointima formation fills the aneurysm and the biologically active DNA molecule released in the aneurysm is absorbed by surrounding tissues of the aneurysm for providing long-term treatment of the aneurysm preventing recanalisation.
A method for reducing or blocking blood flow in a vessel, said method comprising the step of introducing at a desired site in the vessel a slow-releasing, biologically active DNA molecule-leaching device, said device releasing a biologically active DNA molecule at the site for stimulating neointima formation and increasing neointima thickness, said neointima formation reducing or blocking the blood flow in the vessel, said biologically active DNA molecule released at the site is absorbed by surrounding tissues of the vessel for providing long-term vascular reduction or obstruction of the blood flow in the vessel.
A method for sustained vascular occlusion of a blood vessel, said method comprising the step of introducing at a site in the vessel a slow-releasing, biologically active DNA molecule-leaching device, said device releasing a biologically active DNA molecule at the site for stimulating neointima formation and increasing neointima thickness, said neointima formation filling the vessel, said biologically active DNA molecule released at the site is absorbed by surrounding tissues of the vessel for providing long-term vascular occlusion of the blood vessel and preventing recanalisation.
A method for sustained treatment of an aneurysm, said method comprising the step of introducing at an aneurysm site a slow-releasing, biologically active DNA molecule-leaching device, said device releasing a biologically active DNA molecule at the aneurysm site for stimulating neointima formation and increasing neointima thickness, said neointima formation filling the aneurysm, said biologically active DNA molecule released in the aneurysm is absorbed by surrounding tissues of the aneurysm for providing long-term treatment of said aneurysm and preventing recanalisation.
A method for sustained treatment of a hypervascular lesion, said method comprising the step of introducing in the vessel feeding the lesion a slow-releasing, biologically active DNA molecule-leaching device, said device releasing a biologically active DNA molecule in the lesion for stimulating neointima formation and increasing neointima thickness, said neointima formation reducing or blocking blood flow in the vessel at the lesion, said biologically active DNA molecule released at the lesion is absorbed by surrounding tissues of the vessel for providing long-term vascular reduction or blocking of the blood flow in the vessel.
A method for preparing a DNA leaching artificial occlusion device, said method comprising the step of providing a solution of an HPLC-purified DNA and dipping an artificial occlusion device in said solution for adsorbing DNA onto the occlusion device in such a manner that said DNA leaches from said occlusion device.
Dependencies are inferred from the claim text.