Implantable medical devices
AssigneeMayo Foundation for Medical Education and Research
InventorsNoel Caplice, David Berry, Robert S. Schwartz, David R. Holmes JR., Robert D. Simari
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Abstract
Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.
Claims39
An implantable medical device comprising a non-woven framework, wherein said non-woven framework comprises metal fibers and pores having an average size of at least 40 μm.
An implantable medical device comprising a plurality of surfaces, wherein at least a portion of at least one of said plurality of surfaces comprises a non-woven framework, and wherein said non-woven framework comprising pores having an average size of at least 40 μm.
A non-woven framework comprising an extracellular matrix protein, wherein said non-woven framework comprises metal fibers and has an average pore size of at least 40 μm.
A method of delivering a polypeptide to a mammal, said method comprising implanting a medical device in said mammal, wherein said medical device comprises a non-woven framework, said non-woven framework comprising metal fibers and pores having an average size of at least 40 μm, wherein said non-woven framework further comprises an extracellular matrix protein and cells selected from the group consisting of smooth muscle cells, hepatocytes, fibroblasts, and endothelial cells, and wherein said cells express said polypeptide.
A method of delivering a polypeptide to a mammal, said method comprising implanting a medical device in said mammal, wherein said medical device comprises a plurality of surfaces, wherein a non-woven framework is attached to at least a portion of at least one of said plurality of surfaces, said non-woven framework having pores of an average size of at least 40 μm, wherein said non-woven framework further comprises an extracellular matrix protein and cells selected from the group consisting of smooth muscle cells, hepatocytes, fibroblasts, and endothelial cells, and wherein said cells express said polypeptide.
Dependencies are inferred from the claim text.