Enterohemorrhagic escherichia coli vaccine
AssigneesUniversity of Saskatchewan, The University of British Columbia
InventorsBrett Finlay, Andrew A. Potter
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Abstract
Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
Claims34
A vaccine composition comprising an enterohemorragic Escherichia coli (EHEC) cell culture supernatant and an immunological adjuvant.
A method for eliciting an immunological response in a mammal against a secreted enterohemorragic Escherichia coli (EHEC) antigen, said method comprising administering to said mammal a therapeutically effective amount of a composition comprising an EHEC cell culture supernatant.
A method for eliciting an immunological response in a ruminant against a secreted enterohemorragic Escherichia coli O157:H7 (EHEC O157:H7) antigen, said method comprising administering to said ruminant a therapeutically effective amount of a composition comprising an EHEC O157:H7 cell culture supernatant and VSA3.
A method for reducing colonization of enterohemorragic Escherichia coli (EHEC) in a ruminant comprising administering to said ruminant a therapeutically effective amount of a composition comprising an EHEC cell culture supernatant and an immunological adjuvant.
A method for reducing shedding of enterohemorragic Escherichia coli (EHEC) from a ruminant comprising administering to said ruminant a therapeutically effective amount of a composition comprising an EHEC cell culture supernatant and an immunological adjuvant.
Dependencies are inferred from the claim text.