Association of mhc class II allenles and cancer
OwnerShiv Pillai, Cariappa Annaiah +2inventors
InventorsShiv Pillai, Cariappa Annaiah, David Forcione, Subhra Chaudhuri
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Abstract
Particular HLA alleles are found to be associated with human cancer Some HLA alleles are negatively associated with cancer, whereas others show a positive association. This discovery suggests that the immune system plays an important role in the detection and elimination of human tumors. The invention includes methods of determining susceptibility to cancer as well as prognosis. The invention further includes methods of treatment of cancer wherein expression of a particular HLA allele is modulated
Claims49
A method of evaluating an individual's susceptibility to cancer, the method comprising:
- determining that the individual bears an HLA DQB1*03032 allele, and
- classifying the individual as having a low susceptibility to cancer based upon the presence of the HLA DQB1*03032 allele.
A method of evaluating an individual's susceptibility to cancer, the method comprising:
- determining that the individual bears an HLA DRB1*11 allele, and
- classifying the individual as having a low susceptibility to cancer based upon the presence of the HLA DRB1*11 allele.
A method of evaluating an individual's susceptibility to cancer, the method comprising:
- determining that the individual bears an HLA DRB3*02 allele, and
- classifying the individual as having a high susceptibility to cancer based upon the presence of the HLA DRB3*02 allele.
A method of evaluating the prognosis of an individual suspected of having cancer, the method comprising:
- determining that the individual bears an HLA DQB1*03032 allele, and
- classifying the individual as having a positive prognosis based upon the presence of the HLA DQB1*03032 allele.
A method of evaluating the prognosis of an individual suspected of having cancer, the method comprising:
- determining that the individual bears an HLA DRB1*11 allele, and
- classifying the individual as having a positive prognosis based upon the presence of an HLA DRB1*11 allele.
A method of evaluating the prognosis of an individual suspected of having cancer, the method comprising:
- determining that the individual bears an HLA DRB3*02 allele, and
- classifying the individual as having a poor prognosis based upon the presence of the HLA DRB3*02 allele.
A method of treating an individual, the method comprising introducing into the individual an expression vector coding for expression of HLA DQB1*03032.
A method of treating an individual, the method comprising introducing into the individual an expression vector coding for expression of an HLA DRB1*11 molecule.
A method of treating an individual, the method comprising
- determining that the individual does not express HLA DQB1*03032, and
- introducing into the individual cells expressing HLA DQB1*03032.
A method of treating an individual, the method comprising
- determining that the individual does not express an HLA DRB1*11 allele, and
- introducing into the individual cells expressing an HLA DRB1*11 allele.
Dependencies are inferred from the claim text.