Biotin derivatives
OwnerBengt E.B. Sandberg, D. Scott Wilbur +1inventors
InventorsBengt E.B. Sandberg, D. Scott Wilbur, Rune Nilsson
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Abstract
A method for the conditioning of an extracorporeal device is described, as well as a method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.
Claims20
Method for the conditioning of an extracorporeal device for the extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, wherein a solution containing a reagent having the general formula:
- 10
- wherein the biotin moieties are natural biotin or derivatives thereof,
- wherein a, b, and c are linkers, which are same or different, and wherein d is a tri-functional crosslinking moiety,
- is passed through a device having biotin binding ability, wherein the reagent is bound to the device, and wherein said device thereby is converted from a biotin binding to a toxic material binding device.
Method according to any of the previous claims, wherein the toxin binding moiety is biotin, the spacers a, b, and c are 4,7,10-trioxa-1,13-tridecanediamine and the trifunctional cross-linking moiety is 5-amino-1,3-dicarboxybenzene.
Dependencies are inferred from the claim text.