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US 2002/0159986 A1Published application
Bone morphogenetic protein-2 in the treatment and diagnosis of cancer
OwnerJohn Langenfeldinventor
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OwnerJohn Langenfeldinventor
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The present invention pertains to the use of BMP-2, which is overexpressed in most common cancers, as 1) a target for cancer treatment therapies and 2) a means to diagnose cancer. The therapeutic component of this invention involves administering to a patient a composition that inhibits bone morphogenetic-2 activity. Such inhibition may be accomplished by ligands or antibodies that bind to BMP-2 or BMP-2 receptors. It may also be achieved by preventing the processing of pro-BMP-2, or blocking transcription or replication of BMP-2 DNA or translation of BMP-2 mRNA. The diagnostic component of the invention involves measuring the BMP-2 level in biological samples from both a patient and a non-cancerous subject and comparing those levels. Elevated levels of BMP-2 in the patient compared to the subject indicate cancer.
A method for the treatment of cancer comprising administering to a patient a therapeutically effective amount of a bone morphogenetic protein-2 activity inhibitor.
A method for the treatment of cancer comprising administering to a patient a therapeutically effective amount of an expression vector having a nucleic acid sequence encoding a bone morphogenetic protein-2 activity inhibitor.
A method for the treatment of cancer comprising administering to a patient a therapeutically effective amount of an expression vector encoding an antisense oligonucleotide that binds to a bone morphogenetic protein-2 nucleic acid sequence.
An article of manufacture comprising packaging material and, contained within the packaging material, a compound that is a bone morphogenetic protein-2 activity inhibitor, wherein the packaging material indicates that the compound can be used for treating cancer in a patient.
A method for the diagnosis of cancer in a patient, comprising
A method for the diagnosis of cancer in a patient, which method comprises detecting the overexpression of bone morphogenetic protein-2 in the patient, the overexpression of bone morphogenetic protein-2 indicating the presence of cancer, the method comprising the steps of:
Dependencies are inferred from the claim text.