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OwnerMichel Houde, Ghislain M. M. Opdenakker +1inventors
InventorsMichel Houde, Ghislain M. M. Opdenakker, Rosemonde Mandeville
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The present invention relates to methods and pharmaceutical compositions for the treatment of neutrophil-mediated diseases in humans and animals. More particularly, the present invention is concerned with methods and compositions for preventing and treating diseases such as cancer as well as acute and chronic inflammation by specifically neutralizing the biological activity of a neutrophil-secreted matrix metalloproteinase (MMP). According to a preferred embodiment of the invention, the neutrophil-secreted MMP that is targeted is MMP-9 (gelatinase B). According to the invention, the beneficial effects conferred by the specific neutralization of a neutrophil-secreted MMP, and more particularly MMP-9, are not counterbalanced by the detrimental effects of a broad and non-specific inhibition of other MMPs.
A method for the prevention or treatment of a neutrophil-mediated inflammatory disorder, comprising the step of specifically neutralizing the biological activity of a neutrophil-secreted matrix metalloproteinase (MMP).
A method for the prevention or treatment of a neutrophil-mediated disease in a human or an animal, comprising administering to said human or animal a pharmaceutically effective amount of an inhibitor that neutralizes specifically the biological activity of a neutrophil-secreted matrix metalloproteinase (MMP).
Dependencies are inferred from the claim text.