Small peptide-based therapeutics for reversing cancer-associated MUC-1 mucin-induced immunosuppression
OwnerBabita Agrawal, Bryan Michael Longenecker +1inventors
InventorsBabita Agrawal, Bryan Michael Longenecker, Mark Austin Reddish
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Abstract
The invention relates to derivatives of MUC-1 mucin which are particularly useful in relieving states of anergy or immunosuppression. MUC-1 derivatives, pharmaceutical compositions containing them, and methods of using them are also provided.
Claims13
A MUC-1 derivative, consisting essentially of a single MUC-1 core repeat.
A MUC-1 derivative, comprising the amino acid sequence GVTSAPDTRPAPGSTA, wherein said derivative is less than 60 amino acids in length.
A MUC-1 derivative, comprising a single MUC-1 core repeat, or a derivative thereof, linked to a cytokine.
A pharmaceutical composition, comprising a MUC-1 derivative and a pharmaceutically acceptable excipient.
A method of treatment, comprising administering to a patient in need of treatment a MUC-1 derivative in an amount sufficient substantially to alleviate immunosuppression or anergy.
Dependencies are inferred from the claim text.