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US 2002/0159953 A1Published application
Method to diagnose and monitor cellular immune deficiencies
OwnerJohn W. Haddeninventor
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OwnerJohn W. Haddeninventor
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A method and kit for determining candidates for immunotherapy, for monitoring the effect of immunotherapy and analysis of cell mediated immunity functionality in a patient who needs immunotherapy is provided. The method includes performing two intracutaneous skin tests and reading the skin test after twenty-four hours. One skin test is the administration of a mitogen such as phytohemagglutinin (PHA), concanavalin A (ConA), pokeweed antigen (PWA) and other mitogens as known in the art. The PHA skin test responses reflect the ability of the T-lymphocytes which are present to react to PHA and to release cytokines like IL-2 and induce a monocyte/macrophage infiltration leading to the DTH dermal reaction which is observed in the skin test characteristic of the afferent limb response of the immune system. The NCM (mitogen-stimulated natural cytokine mixture) skin test reflects the ability of preformed T-cell cytokines to induce the monocyte/macrophage accumulation characteristic of the efferent limb response.
A method for monitoring the effect of immunotherapy in a patient undergoing immunotherapy including the steps of
A method to analyze cell mediated immunity in a patient needing such an analysis including the steps of
A method for selecting candidates for immunotherapy among patients who need immunotherapy including the steps of
Dependencies are inferred from the claim text.