Novel targeted compositions for diagnostic and therapeutic use
OwnerEvan C. Unger, Thomas P. McCreeryinventors
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Abstract
Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise lipid, protein or polymer gas-filled vesicles which further comprise novel compounds of the general formula L-P-T, wherein L comprises a hydrophobic compound, P comprises a hydrophilic polymer, and T comprises a targeting ligand which targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The compositions can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.
Claims110
A method for providing an image of an internal region of a patient having a vascular plaque, wherein the method comprises (i) administering to the patient a contrast agent comprising, in an aqueous carrier, targeted vesicles formulated from a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque and comprises a phosphorylated serine moiety;
- and (ii) scanning the patient using ultrasound to obtain a visible image of the region.
A method for diagnosing the presence of a vascular plaque in a patient, wherein the method comprises (i) administering to the patient a contrast agent comprising, in an aqueous carrier, targeted vesicles formulated from a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque and comprises a phosphorylated serine moiety;
- and (ii) scanning the patient using ultrasound to obtain a visible image of any plaque in the patient.
A method for the therapeutic delivery in vivo of a bioactive agent to a region in a patient having a vascular plaque, wherein the method comprises administering to a patient a therapeutically effective amount of a formulation comprising, in combination with a bioactive agent, a composition which comprises vesicles formulated from a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque and comprises a phosphorylated serine moiety.
A method of dissolving plaque in a blood vessel comprising (i) administering to a patient, by intravenous injection, a targeted vesicle composition comprising vesicles formulated from a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque;
- (ii) scanning said patient with diagnostic imaging to visualize said plaque;
- and (iii) applying ultrasonic energy to said plaque.
A composition for use in targeting an internal region of a patient having vascular plaque, wherein the composition comprises vesicles formulated from a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque and comprises a phosphorylated serine moiety.
A formulation for therapeutic or diagnostic use in a patient having a vascular plaque, wherein the formulation comprises, in combination with a bioactive agent, a composition comprising vesicles formulated from a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque and comprises a phosphorylated serine moiety.
A process for the preparation of a composition for use in targeting a region in a patient having a vascular plaque, wherein the process comprises combining together a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque and comprises a phosphorylated serine moiety.
A process for the preparation of a formulation for therapeutic or diagnostic use in a patient having a vascular plaque, wherein the process comprises combining together a bioactive agent, a lipid or polymer, a gas or gaseous precursor, a targeting ligand, and optionally, an oil, wherein said targeting ligand targets cells or receptors associated with vascular plaque and comprises a phosphorylated serine moiety.
Dependencies are inferred from the claim text.