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US 2002/0159948 A1Published application
Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
OwnerEdwin L. Adair, Jeffrey L. Adairinventors
Life of this patent
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Abstract
A cancer screening method is provided, wherein the method is characterized by introducing a chemical compound to a patient, the compound being a complex of a fluorescent marker and a radioactive marker. Cells are then collected preferably through non-invasive or minimally invasive means. If fluorescence is observed in the exfoliated cells, tomographic scanning is conducted to further locate and/or confirm suspected malignant areas or metastatic areas. Further observation or treatment may be conducted either through fluorescence guided endoscopy, photo-dynamic therapy, and/or radiation treatment.
Claims22
A method of cancer screening comprising the steps of:
- introducing a compound to a patient for cell uptake of the compound, the compound having a first portion which creates a fluorescent marker and a second portion which creates a radioactive marker in targeted cells, after cell uptake of the compound;
- collecting the targeted cells from the patient;
- stimulating the collected cells by a selected range of frequency of light to cause pre-malignant and malignant cells to fluoresce;
- observing the collected cells to determine if fluorescence occurs in the collected cells indicating the presence of cancer;
- conducting tomographic scanning of the patient after the viewing step if fluorescence was observed;
- and
- conducting fluorescence guided endoscopy for further observation or treatment of pre-malignant or malignant areas found during the first conducting step.
4 more elements
A method of cancer screening comprising the steps of:
- introducing a compound to a patient for cell uptake of the compound, the compound having a first portion which creates a fluorescent marker, and a second portion which creates a radioactive marker in targeted cells, after cell uptake of the compound;
- collecting the targeted cells from the patient;
- stimulating the collected cells by a selected range of frequency of light to cause pre-malignant and malignant cells to fluoresce;
- viewing the collected cells to determine if fluorescence occurs in the collected cells indicating the presence of cancer;
- conducting tomographic scanning of the patient after the viewing step if fluorescence was observed;
- and
- conducting radiation therapy by site selective ionizing radiation treatment.
4 more elements
A method of cancer screening comprising the steps of:
- introducing a compound to a patient for cell uptake of the compound, the compound having a first portion which creates a fluorescent marker, and a second portion which creates a radioactive marker in target cells, after cell uptake of the compound, wherein said first portion of said compound is selected from the group consisting of 5-ALA, protoporphyrin IX, TCPP, hematoporphyrin derivative, photofrin, uroporphyrin, coproporphyrin, TPPS, and TMPP, and said second portion of said compound is selected from the group consisting of radioisotopes of copper which may be complexed with said first portion;
- collecting the targeted cells from the patient;
- stimulating the collected cells by a selected range of frequency of light to cause pre-malignant and malignant cells to fluoresce;
- viewing the collected cells to determine if fluorescence occurs in the collected cells indicating the presence of cancer;
- and
- conducting tomographic scanning of the patient after the viewing step if fluorescence was observed.
3 more elements
A method of cancer screening comprising the steps of:
- introducing a compound to a patient for cell uptake of the compound, the compound having a first portion which creates a fluorescent marker and a second portion which creates a radioactive marker in targeted cells, after cell uptake of the compound;
- collecting the targeted cells from the patient;
- stimulating the collected cells by a selected range of frequency of light to cause pre-malignant and malignant cells to fluoresce;
- observing the collected cells to determine if fluorescence occurs in the collected cells indicating the presence of cancer;
- conducting tomographic scanning of the patient after the viewing step if fluorescence was observed;
- and
- conducting an interventional surgical procedure to treat tissue found to be pre-malignant or malignant.
4 more elements
A method of cancer screening comprising the steps of:
- introducing a compound to a patient for cell uptake of the compound, the compound having a first portion which creates a fluorescent marker, and a second portion which creates a radioactive marker in targeted cells, after cell uptake of the compound;
- collecting the targeted cells from the patient;
- stimulating the collected cells by a selected range of frequency of light to cause pre-malignant and malignant cells to fluoresce;
- conduct tomographic scanning of the patient after the viewing step, positive indications found on the scanning indicating the presence of cancer;
- viewing the collected cells to determine if fluorescence occurs if the scanning indicated the presence of cancer;
- and
- conducting radiation therapy by site selective ionizing radiation treatment.
4 more elements
Dependencies are inferred from the claim text.