Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
AssigneeBristol-Myers Squibb Pharma Company
InventorsRobert Zaczek, Richard E. Olson, Dietmar A. Seiffert, Lorin A. Thompson
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Abstract
This invention relates to a method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Furthermore, radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
Claims52
A method for diagnosing a neurological disease involving APP processing and/or the production of beta-amyloid production within a mammalian body comprising:
- (c) administering a diagnostically effective amount of a radiopharmaceutical inhibitor of APP processing and/or the production of beta-amyloid production;
- and
- (d) imaging the area of the patient wherein the disease is located.
A method for diagnosising a neurological disease involving APP processing and/or the production of beta-amyloid production within a mammalian body comprising:
- (a) administering a diagnostically effective amount of an ultrasound contrast agent composition inhibitor of APP processing and/or the production of beta-amyloid production;
- and
- (b) imaging the area of the patient wherein the disease is located.
A method of in vivo diagnostic imaging comprising administering to a subject a diagnostically effective amount of a radiolabeled inhibitor of beta-amyloid production.
A pharmaceutical composition suitable for in vivo diagnostic imaging comprising a radiolabeled inhibitor of beta-amyloid production.
Dependencies are inferred from the claim text.