Diagnosing and treating cancer cells using Sal2
OwnerThomas L. Benjamin, Dawei Li +3inventors
InventorsThomas L. Benjamin, Dawei Li, Samuel C. Mok, Daniel W. Cramer, Yupo Ma
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Abstract
The invention features the use of Sal2 nucleic acids and proteins in methods for treating patients having proliferative disorders, such as cancers, involving mutations in a Sal2 nucleic acid sequence and in the protein that it encodes. In addition, these treatment methods may also be used for patients having a mutation in a nucleic acid sequence encoding a protein that interacts with Sal2 or that functions in a signaling pathway involving Sal2. Furthermore, Sal2 may be used as an anti-viral agent that interferes with the ability of a DNA tumor virus to replicate and disseminate in a cell.
Claims10
A method of decreasing proliferation of an abnormally proliferating cell, said method comprising the step of contacting said abnormally proliferating cell with a Sal2 nucleic acid sequence, wherein said contacting results in the expression of a Sal2 polypeptide having tumor suppressive activity in said abnormally proliferating cell.
A method of decreasing DNA tumor virus replication and dissemination, said method comprising the step of contacting a cell infected with a DNA tumor virus with a Sal2 nucleic acid sequence, wherein said contacting results in the expression of a Sal2 polypeptide in said cell infected with said DNA tumor virus and prevents said DNA tumor virus from replicating and disseminating.
An isolated Sal2 nucleic acid sequence encoding a polypeptide that contains a substitution of a Cys for the Ser at position 73 of SEQ ID NO:1.
Dependencies are inferred from the claim text.