Function of a haptoglobin-haemoglobin receptor and the uses thereof
AssigneeProteoPharma ApS
InventorsSoren Moestrup, Holger J. Moller
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Abstract
The present invention relates to haptoglobin-haemoglobin (Hp-Hb) complex or a part thereof or a mimic thereof being operably linked to a substance and capable of binding a CD163 receptor. Furthermore, the invention relates to a CD163 variant, membrane bound or soluble, capable of binding at least one haptoglobin-haemoglobin (Hp-Hb) complex, and the use of the Hp-Hb complex and the CD163 receptor for therapy.
Claims37
A Hp-Hb complex (haptoglobin-haemoglobin complex) or a part thereof or a mimic thereof being operably linked to a substance, wherein the Hp-Hb complex or the part thereof or the mimic thereof is capable of binding a CD163 receptor and/or a CD163 receptor variant.
The Hp-Hb as mimic, according to any of the claims, wherein the mimic is an antibody.
A CD163 variant capable of binding at least one haptoglobin-haemoglobin (Hp-Hb) complex.
Dependencies are inferred from the claim text.