# US 2002/0147451 A1 · Method of restructuring bone > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2002/0147451 A1 - Document ID: US20020147451A1 - Status: Published application - Kind: A1 - Application number: 10/104,063 - Filed: 2002-03-25 - Published: 2002-10-10 - Earliest claimed: 1995-07-18 - Assignees: Iowa State University Research Foundation, Inc. - Inventors: Thomas D. McGee - Web page: https://patentgrep.com/patent/US20020147451A1 ## CPC - A61L 27/12: Phosphorus-containing materials, e.g. apatite - A61F 2/28: Bones - A61F 2/32: for the hip - A61L 27/105: {containing Al2O3} - A61L 31/026: {Ceramic or ceramic-like structures, e.g. glasses} - A61B 17/72: Intramedullary devices, e.g. pins or nails - A61B 17/80: Cortical plates {, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates} - A61B 17/848: {Kirschner wires, i.e. thin, long nails} - A61B 17/86: Pins or screws {or threaded wires; nuts therefor (A61B17/72 take precedence)} - A61F 2/34: Acetabular cups - A61F 2/3601: {for replacing only the epiphyseal or metaphyseal parts of the femur, e.g. endoprosthetic femoral heads or necks directly fixed to the natural femur by internal fixation devices (non-prosthetic internal fixation devices for the femoral head or neck A61B17/74)} - A61F 2002/2825: {Femur} - A61F 2002/2835: {Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material} - A61F 2002/30235: {tubular, e.g. sleeves} - A61F 2002/30662: {with rotation-limiting means} - A61F 2002/30828: {parallel} - A61F 2002/3233: {having anti-luxation means for preventing complete dislocation of the femoral head from the acetabular cup} - A61F 2002/3241: {having a ring, e.g. for locking the femoral head into the acetabular cup} - A61F 2230/0069: cylindrical - A61F 2310/00011: Metals or alloys - A61F 2310/00209: Corundum or Sapphire - A61F 2310/00293: containing a phosphorus-containing compound, e.g. apatite - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A method of producing reconstructed bone. The method includes providing an implant structure having a calcium phosphate component, and stabilizing the implant adjacent the healthy bone until tissue can recover, bond to the implant and support the normal required loading. The implant structure provides morphological continuity and anatomical contact between the implant body and the adjacent healthy bone. The method further includes providing for physiological processes to maintain a healthy junction between the implant and the healthy bone. The method further includes controlling, guiding and directing the bone reconstruction process in surgical situations where healthy recovery would not otherwise occur. ## Claims ### Claim 1 A method of replacing bone in the skeletal structure of a human or animal for inducing repair of a portion of damaged bone and bonding of the damaged bone to the bone replacement at the implant site, comprising: providing a bone replacement prosthesis containing calcium phosphate and having an external geometry to match the geometry of the damaged bone; providing openings in said prosthesis to permit new bone tissue to grow into the prosthesis, and wherein said openings permit blood and lymph systems normally present to operate to support healthy new bone in said openings; matching the surface geometry of the bone contact areas of the prosthesis to the contact areas of bone at the implant site; positioning said replacement prosthesis in contact with adjacent bone; and stabilizing said prosthesis for a sufficient time for said bone to bond to said prosthesis. ### Claim 2 (depends on 1) The method of claim 1 wherein said prosthesis is in the shape of a hollow cylinder. ### Claim 3 (depends on 1) The method of claim 1 wherein said prosthesis is positioned between bone and a metal, ceramic or plastic component of a second prosthesis. ### Claim 4 (depends on 3) The method of claim 3 wherein said second prosthesis comprises an articulating joint. ### Claim 5 (depends on 1) The method of claim 1 wherein said prosthesis is inserted into a defect in laminar bone and wherein said openings for bone ingrowth are positioned in the blood supply layer between the external cortices of said laminar bone. ### Claim 6 (depends on 2) The method of claim 2 wherein said hollow cylinder comprises an osteoceramic cyclinder and the thickness of the wall of the osteoceramic cylinder matches the thickness of the wall of the damaged bone. ### Claim 7 (depends on 1) The method of claim 1 where said prosthesis has a strength equal to or greater than the bone normally present at the implant site. ### Claim 8 (depends on 1) The method of claim 1 wherein said prosthesis is shaped to accommodate the defect geometry of the damaged bone. ### Claim 9 (depends on 1) The method of claim 1, further comprising maintaining natural blood and lymphatic service to the damaged bone and to the new bone tissue in said openings. ### Claim 10 (depends on 1) The method of claim 1, wherein said step of stabilization further comprises attaching a bone plate to said prosthesis and attaching the plate to adjacent bone. ### Claim 11 A method of incorporating a prosthetic device into the skeletal structure of a human or animal for inducing bone repair of a portion of damaged bone and bonding to the prosthesis, comprising the steps of: providing a hollow osteoceramic cylinder having an outer surface, a first end, a second end, and a plurality of notches in at least one of the first and the second ends, wherein the osteoceramic cylinder has a surface geometry configured to match a surface geometry of the damaged bone; positioning the osteoceramic cylinder so that the plurality of notches are adjacent to the damaged bone; and stabilizing the osteoceramic cylinder for a time sufficient for bone tissue to grow into the plurality of notches. ### Claim 12 (depends on 11) The method of claim 11, wherein said step of providing the hollow osteoceramic cylinder further comprises matching the thickness of the osteoceramic cylinder with the thickness of the damaged bone. ### Claim 13 (depends on 11) The method of claim 11, wherein said step of providing the hollow osteoceramic cylinder further comprises selecting an osteoceramic cylinder having an equal or greater tensile strength than the damaged bone. ### Claim 14 (depends on 11) The method of claim 11, wherein said step of providing the hollow osteoceramic cylinder further comprises shaping the osteoceramic cylinder to accommodate the defect geometry of the damaged bone. ### Claim 15 (depends on 11) The method of claim 11, further comprising maintaining natural blood and lymphatic service to the damaged bone and bone tissue. ### Claim 16 (depends on 11) The method of claim 11, wherein said step of stabilizing the osteoceramic cylinder further comprises attaching a plate to the osteoceramic cylinder and attaching the plate to the damaged bone. ### Claim 17 A method of incorporating a bone guide into the skeletal structure of a human or animal for inducing bone repair in a first and a second portion of damaged bone, comprising the steps of: providing a calcium phosphate cylinder adapted to fit into the intramedullary cavity of the damaged bone; positioning the cylinder inside the intramedullary cavities of the first and the second portions of damaged bone; and stabilizing the first and second portions of damaged bone with respect to each other for a time sufficient for bone tissue to grow to connect the first and second portions of bone. ### Claim 18 (depends on 17) The method of claim 17, wherein said cylinder is adapted to fit loosely into the intramedullery cavity of at least one of the first and second portions of damaged bone. ### Claim 19 (depends on 17) The method of claim 17, wherein said cylinder is positioned to provide a space between said cylinder and at least one of said first and second portions of damage bone to allow for blood supply from the intramedullary cavity. ### Claim 20 (depends on 17) The method of claim 17, wherein said stabilizing step comprises connecting the first and second portions of damaged bone with one or more bone attachment means. ### Claim 21 (depends on 20) The method of claim 20, wherein said bone attachment means comprises a bone plate. ### Claim 22 (depends on 17) The method of claim 17, wherein said cylinder comprises an osteoceramic material. ### Claim 23 A method of incorporating a prosthetic device into the skeletal structure of a human or animal for inducing bone repair and stabilizing a first and a second portion of damaged bone, comprising the steps of: providing an osteoceramic cylinder adapted to tightly fit into the intramedullary cavity of the damaged bone; positioning the osteoceramic cylinder inside the intramedullary cavities of the first and the second portions of damaged bone; and stabilizing the osteoceramic cylinder relative to the first and second portions of damaged bone. ### Claim 24 (depends on 23) The method of claim 23, wherein said step of stabilizing the osteoceramic cylinder further comprises positioning osteoceramic spacers on the outer surface of the osteoceramic cylinder. ### Claim 25 (depends on 23) The method of claim 23, wherein said step of stabilizing the osteoceramic cylinder further comprises connecting the osteoceramic cylinder to at least one of the first and second portions of damaged bone with one or more bone attachment means. ### Claim 26 (depends on 23) The method of claim 23, wherein the animal is an avian and the cylinder is hollow. ### Claim 27 A method of incorporating a joint replacement device into the skeletal structure of a human or animal for articulably connecting a first and a second bone, comprising the steps of: providing a joint replacement device having a sapphire or ruby ball, first and second bearing surfaces contacting the ball and permitting relative movement of the ball therewithin, a first retainer for holding the first bearing surface and having a first osteoceramic body with a first bone contact surface thereon, and a second retainer for holding the second bearing surface and having a second osteoceramic body with a second bone contact surface thereon, wherein the first and second bone contact surfaces have surface geometries configured to match the surface geometries of the first and second bone, respectively; positioning the joint replacement device in an orthopedically desirable position between the first and the second bones; and reattaching or repositioning ligaments to maintain natural blood and lymphatic service to the first and second bones. ### Claim 28 (depends on 27) The method of claim 27, further comprising the step of stabilizing the joint replacement device by attaching the first bone contact surface to the first bone, and the second bone contact surface to the second bone. ### Claim 29 (depends on 28) The method of claim 28, wherein said step of stabilizing the joint replacement device further comprises attaching the first bone contact surface to the first bone and the second bone contact surface to the second bone with bone attachment means. ### Claim 30 (depends on 27) The method of claim 27, further comprising the step of stabilizing the joint replacement device by reattaching tendons and ligaments to the first and second bones. ### Claim 31 (depends on 27) The method of claim 27, wherein the joint replacement device is selected from the group consisting of an artificial hip, elbow, knee, shoulder, and spine. ### Claim 32 (depends on 27) The method of claim 27, wherein the joint replacement device is an artificial hip. ### Claim 33 (depends on 32) The method of claim 32, wherein the first bone is a femur, and wherein the ball of the femur is reamed into a frustrum of a cone shape prior to attaching the first bone contact surface thereto. ### Claim 34 (depends on 32) The method of claim 32, wherein the first bone is a femur, and wherein said step of positioning the joint replacement device further comprises removing the stem of the femur and inserting an intramedullary extension of the first osteoceramic body into the intramedullary cavity of the femur.