Corpuscles of stannius protein, stanniocalcin
AssigneeHuman Genome Sciences, Inc.
InventorsHenrik S. Olsen, Mark D. Adams
Life of this patent
Estimating the term…
Abstract
The present invention relates to human Corpuscles of Stannius polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antagonists against such polypeptides. Human Corpuscles of Stannius protein inhibits calcium uptake and reduces renal excretion of phosphate. Also provided is a diagnostic assay to detect mutations in the nucleic acid sequence encoding the polypeptide and for altered concentrations of the polypeptide in a sample derived from a host.
Claims22
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide comprising amino acids -35 to 212 of SEQ ID NO:2;
- (b) a polynucleotide encoding the polypeptide comprising amino acids 1 to 212 of SEQ ID NO:2;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a) or (b).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide which encodes a polypeptide having the amino acid sequence expressed by the DNA contained in ATCC Deposit No. 75652;
- (b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and (c)a polynucleotide fragment of the polynucleotide of (a) or (b).
A polypeptide selected from the group consisting of:
- (i) a polypeptide having the deduced amino acid sequence of SEQ ID NO:2 and fragments, analogs and derivatives thereof;
- and
- (ii) a polypeptide encoded by the cDNA of ATCC Deposit No. 75652 and fragments, analogs and derivatives of said polypeptide.
Dependencies are inferred from the claim text.