Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
AssigneeExpression Genetics, Inc.
InventorsCheol Hee Ahn, Sung Wan Kim
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Abstract
A biodegradable, novel cationic coopolymer comprising a a poly(alkylenimine)(PAI), a hydrophilic polymer, and a biodegradable linker, wherein the biodegradable linker covalently links the PAI and the hydrophilic polymer. The biodegradable cationic copolymers in the present invention can be used in drug delivery and are especially useful for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.
Claims27
A biodegradable cationic copolymer comprising a poly(alkylenimine)(PAI), and a hydrophilic polymer, wherein the PAI is linked with the hydrophilic polymer by a biodegradable linkage.
A biodegradable cationic copolymer comprising a poly(alkylenimine)(PAI), and a hydrophilic polymer, wherein the PAI is linked with the hydrophilic polymer by a biodegradable linkage selected from the group consisting of ester, amide and urethane.
A biodegradable cationic copolymer comprising a poly(ethylenimine)(PEI),and a hydrophilic polymer, wherein the PEI is linked with the hydrophilic polymer by a biodegradable linkage selected from the group consisting of ester, amide and urethane.
A biodegradable cationic copolymer comprising a poly(alkylenimine)(PAI), and hydrophilic polymer selected from the group consisting of polyethylene glycol (PEG), poloxamers, poly(acrylic acid), poly(styrene sulfonate), carboxymethylcellulose, poly(vinyl alcohol), polyvinylpyrrolidone, alpha-substituted poly(oxyalkyl) glycols, poly(oxyalkyl) glycol copolymers and block copolymers, wherein the PAI is linked with the hydrophilic polymer by a biodegradable linkage selected from the group consisting of ester, amide and urethane.
A biodegradable cationic copolymer comprising a poly(ethylenimine)(PEI), and hydrophilic polymer selected from the group consisting of polyethylene glycol (PEG), poloxamers, poly(acrylic acid), poly(styrene sulfonate), carboxymethylcellulose, poly(vinyl alcohol), and polyvinylpyrrolidone, wherein the PAI is linked with the hydrophilic polymer by a biodegradable linkage selected from the group consisting of ester, amide and urethane.
A biodegradable cationic copolymer comprising a poly(alkylenimine)(PAI) and polyethylene glycol (PEG), wherein the PAI is linked with the PEG by a biodegradable linkage selected from the group consisting of ester, amide and urethane.
A biodegradable cationic copolymer comprising a poly(ethylenimine)(PEI), and polyethylene glycol (PEG), the PEI is linked with the PEG by a biodegradable linkage selected from the group consisting of ester, amide and urethane.
Dependencies are inferred from the claim text.