Magnetic particles for diagnostic purposes
OwnerHeinz Gries, Wolfgang Mutzel +2inventors
InventorsHeinz Gries, Wolfgang Mutzel, Christian Zurth, Hanns-Joachim Weinmann
Life of this patent
Estimating the term…
Abstract
Agents containing magnetic particles are suitable for use in enhancing images in diagnostic procedures, e.g., via x-ray, ultrasound or especially NMR. Preferred particles are based on metals, e.g., iron, cobalt or nickel, double metal oxides/hydroxides or complexes thereof.
Claims84
A pharmaceutical composition useful in diagnostic medical procedures comprising a pharmaceutically acceptable carrier and a physiologically compatible magnetic material in particulate form, with the proviso that the magnetic material is not magnetite-dextran, magnetite-human serum albumin or magnetite-oleic acid.
A composition of claim 50 wherein the double metal oxide/hydroxide is a ferrite of the formula mMO.n Fe2O3, wherein M is a bivalent metal ion and each of m and n independently is a number 1-6.
A composition of claim 50 wherein the double metal oxide/hydroxide is of the formula nFeO.mM2O3, wherein M is a trivalent metal ion and each of m and n independently is a number 1 to 6.
A composition of claim 50 wherein the complexing agent is human serum albumin.
A composition of claim 50 wherein the complexing agent is dextran.
A composition of claim 50 wherein the particulate material is glucose-magnetite.
A composition of claim 50 wherein the particulate material is dextrin-magnetite.
A composition of claim 50 wherein the particulate material is dextran-zinc ferrite.
A composition of claim 50 wherein the particulate material is oleic acid-zinc ferrite.
A composition of claim 50 wherein the particulate material is oleic acid-barium ferrite.
A composition of claim 50 wherein the particulate material is dextran-barium ferrite.
A composition of claim 50 which is a fluid containing said particulate magnetic material in an amount of 1 umole to 1 mole of magnetic metal per liter.
A magnetic complex of Fe2O3, or of a double metal-oxide/hydroxide
- of the formula mMO.nFe2O3, wherein M is a bivalent metal ion or a mixture of two bivalent metal ions,
- or of the formula nFeO.mM2O3, wherein M is a trivalent metal ion,
- and each of m and n independently is a number 1 to 6,
- with a water-soluble-mono-, di-, oligo- or polysaccharide, a protein or a carboxylic acid as complexing agent,
- with the proviso that the double metal-oxide/hydroxide is not magnetite when the complexing agent is human serum albumin, dextran or oleic acid.
A method of performing an NMR image comprising administering an NMR image enhancing agent to a patient in conjunction with an NMR measurement, wherein the agent comprises a physiologically compatible magnetic material in particulate form of claim 50.
A method of performing an x-ray diagnosis comprising administering an x-ray image enhancing agent to a patient in conjunction with an x-ray measurement, wherein the agent comprises a physiologically compatible magnetic material in particulate form, with the proviso that the agent is not iron oxide-dextran.
A method of performing an ultrasound diagnosis comprising administering an ultrasound image enhancing agent to a patient in conjunction with an ultrasound measurement, wherein the agent comprises a physiologically compatible magnetic material in particulate form.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and magnetic particles comprising Fe2O3 or a double-metal oxide/hydroxide and a complexing agent, which is an alkali-treated mono-, di-, oligo-, or poly-saccharide, a protein or a carboxylic acid.
A magnetic complex of Fe2O3 or of a double-metal oxide/hydroxide of general formula mMO.nFe2O3, in which M is a divalent metal ion or a mixture of two divalent metal ions, or of general formula nFeO.mM2O3, in which M is a trivalent metal ion, and m and n independently are 1-6, and of a water-soluble, alkali-treated mono-, di-, oligo- or poly-saccharide, a protein or a carboxylic acid as complexing agent, with the proviso that, if the complexing agent is human serum albumin or oleic acid, the double-metal oxide-hydroxide is not magnetite.
A magnetic complex of clam 57 of an average particle diameter less than about 150 Å.
A method of obtaining an NMR image comprising administering carboxylated dextran.
Dependencies are inferred from the claim text.