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US 2002/0132011 A1Published application
Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
AssigneeInhale Therapeutic Systems
InventorsMarc S. Gordon, Andrew Clark, Thomas K. Brewer
Life of this patent
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Abstract
Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
Claims17
A method for preparing a dry powder composition, said method comprising:
- preparing an aqueous solution of a hydrophilic component;
- preparing an organic solution of a hydrophobic component in an organic solvent;
- and
- spray drying the aqueous solution and the organic solution simultaneously to form particles comprising a mixture of the hydrophilic and hydrophobic component.
1 more element
Dependencies are inferred from the claim text.