Methods for expressing gene products

Abstract

The invention provides a method for modulating the amount of a transgene product in a host organism. In one aspect, the invention is used to provide large quantities of a desired transgene product in a transgenic animal, which can then be isolated to produce pharmaceutical compositions in which the transgene product is the active ingredient. In one aspect, the method comprises the steps of providing a host organism comprising a regulatable population of cells which express a transgene encoding the transgene product and administering an agent that regulates the number of transformed cells, allowing the level of the transgene to be modulated. The regulatable population of cells can be transformed with the transgene and introduced into the host organism or the regulatable population of cells comprising the transgene can be generated by germline transformation of a transgenic animal after transformation of one or more germline cells with the transgene.

Dependencies are inferred from the claim text.