Substituted hydrazine derivatives

A compound of the structure

• 38
• wherein R1 and R4 are each independently an aryl group;
• and
• R2 and R3 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, aliphatic acyl, —C1-C3 alkylamino, alkenylamino, alkynylamino, di(C1-C3 alkyl)amino, —C(O)O—(C1-C3 alkyl), —C(O)NH—(C1-C3 alkyl), —CH═NOH, —C(O)N(C1-C3 alkyl)2, haloalkyl, alkoxycarbonyl, alkoxyalkoxy, carboxaldehyde, carboxamide, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, aroyl, aryloxy, arylamino, biaryl, thioaryl, heterocyclyl, heterocycloyl, alkylaryl, aralkenyl, aralkyl, alkylheterocyclyl, heterocyclylalkyl, —SO2—(C1-C3 alkyl), —SO3—(C1-C3 alkyl), sulfonamido, carbamate, aryloxyalkyl, carboxyl, —C(O)NH(benzyl) and —(CH2)tR5;
• wherein R5 is selected from the group consisting of hydrogen, amino, hydroxy, alkoxy, aliphatic acyl, —CN, carboxyl, carboxamide, alkoxycarbonyl, —C(O)NHOH, —C(O)NHNH2 and carboxaldehyde;
• and
• t is an integer of one to four;
• wherein R1, R2, R3, R4and R5 are unsubstituted or substituted with at least one electron donating or electron withdrawing group;
• and wherein R2 and R3 taken together may form a ring;
• and pharmaceutically acceptable salts thereof.