Method for making 8-hydroxyjulolidine compound

Abstract

The present invention relates to 8-hydroxyjulolidine, its analogous compounds and their preparation methods. The invented method comprises one single step of cyclization reactions of 3-aminophenol or 1,3-dihydroxyaniline with 1,3-dihalopropane or its analogs, to prepare the desired julolidines with improved yields. The products of this invention have the following structures: 1 wherein R1 and R2 represent independently H, halogen, hydroxyl or alkyl. The method of this invention includes the following chemical reaction: 2 wherein X and Y represent independently halogen, acyloxyl, sulfonyloxyl or phosphoryloxyl and R1 and R2 are as defined above. This invention also discloses method for the preparation of various coumarins by additionally reacting the produced 8-hydroxyjulolidine and its analogs with appropriate reagents such as malonate and acetoacetate. This invention also discloses the products and intermediates prepared therefrom.

Dependencies are inferred from the claim text.