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US 2002/0120141 A1Published application
Dye labeled imidazoquinoline compounds
Assignee3M Innovative Properties Company
InventorsMichael J. Rice, Mark A. Tomai, Ai-Ping Wei
Life of this patent
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Abstract
Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.
Claims16
A compound of the formula (I):
- 10
- wherein:
- R1 is a spacer group;
- R2 is hydrogen, alkyl, hydroxyalkyl, haloalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, amidoalkyl, alkylamidoalkyl, dialkylamidoalkyl, alkanoylalkyl, azidoalkyl, carbamoylalkyl, alkyl optionally interrupted by a heteroatom;
- alkenyl, alkenyloxyalkyl;
- cycloalkylalkyl, heterocycloalkyl;
- aryl, aralkyl, aralkenyl, heteroarylalkyl, in which aryl is optionally substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halo, amino, alkylamino or dialkylamino;
- aroylalkyl, or heteroaroylalkyl;
- R3 and R4 are each independently hydrogen, alkyl, alkoxy of 1 to 4 carbon atoms, halo, amino, alkylamino, dialkylamino, or when taken together, R3 and R4 form a fused aryl or heteroaryl group that is optionally substituted by one or more substituents selected from alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halo, amino, alkylamino, dialkylamino, hydroxy and alkoxymethyl;
- or
- R3 and R4 for a fused 5- to 7-membered saturated ring, optionally containing one or more heteroatoms and optionally substituted by one or more substituents selected from alkyl of 1 to 4 carbon atoms, halo or haloalkyl of 1 to 4 carbon atoms;
- and
- DYE is a dye moiety, with the proviso that the dye moiety is not dansyl;
- or a pharmaceutically acceptable acid addition salt thereof.
11 more elements
Dependencies are inferred from the claim text.