Human vascular endothelial growth factor 2
AssigneeHuman Genome Sciences, Inc.
InventorsCraig A. Rosen, Jing-Shan Hu, Liang Cao
Life of this patent
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Abstract
Disclosed is a human VEGF2 polypeptide and DNA (RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
Claims20
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide as set forth in SEQ ID NO:
- 2;
- (b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and (c) a polynucleotide fragment of the polynucleotide of (a) or (b).
An isolated polynucleotide comprising a member selected from the group consisting of
- (a) a polynucleotide which encodes a mature polypeptide encoded by the DNA contained in ATCC Deposit No. 97149;
- (b) a polynucleotide which encodes a polypeptide expressed by the DNA contained in ATCC Deposit No. 97149;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
A polypeptide selected from the group consisting of:
- (i) a polypeptide having the deduced amino acid sequence of SEQ ID NO:
- 2 and fragments, analogs and derivatives thereof;
- (ii) a polypeptide comprising amino acid 1 to amino acid 373 of SEQ ID NO:
- 2;
- and
- (iii) a polypeptide encoded by the cDNA of ATCC Deposit No. 97149 and fragments, analogs and derivatives of said polypeptide.
Dependencies are inferred from the claim text.