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AssigneeThe Ohio State University Research Foundation
InventorsYasuko Rikihisa, Norio Ohashi
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Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins of E. chaffeensis and variants thereof, referred to hereinafter as the “OMP proteins”, a group of outer membrane proteins of E. canis and variants thereof referred to hereinafter as the “P30F proteins”, and antibodies to the OMP proteins and the P30F proteins. The OMP proteins of E. chaffeensis encompass OMP-1, OMP-1A, OMP1-B, OMP-1C, OMP1-D, OMP1-E, OMP1-F, OMP1-H, OMP-1R, OMP-1S, OMP-1T, OMP-1U, OMP-1V, OMP-1W, OMP-1X, OMP-1Y and OMP-1Z. The P30F proteins of E. canis encompass P30, P30a, P30-1, P30-2, P30-3; P30-4, P30-5, P30-6, P30-7, P30-8, P30-9, P30-10, P30-11, and P30-12. Isolated polynucleotides that encode the E. chaffeensis OMP proteins and isolated polynucleotides that encode the E. canis P30F protein are also provided. The present invention also relates to kits containing reagents for diagnosing human ehrlichiosis and canine ehrlichiosis, and to immunogenic compositions containing one or more OMP proteins or P30F proteins.
An isolated polynucleotide encoding an outer membrane protein of E. canis, a variant of said outer membrane protein, or an antigenic fragment of said protein;
An isolated polynucleotide encoding an outer membrane protein of E. chaffeensis, a variant of said outer membrane protein, or a an antigenic fragment of said outer membrane protein, wherein the outer membrane protein is selected from the group consisting of OMP-1, OMP-1A, OMP-1R, OMP-1S, OMP-1T, OMP-1U, OMP-1V, OMP-1W, OMP-1X, OMP-1Y, OMP-1Z, and OMP-1H.
An isolated polypeptide selected from the group consisting of the P30 protein, a variant of the P30 protein, an antigenic fragment of the P30 protein, the P30a protein, a variant of the P30a protein, the P30-1 protein, a variant of the p30-1 protein, the P30-2 protein, a variant of the P30-2 protein, the P30-3 protein, a variant of the P30-3 protein, the P30-4 protein, a variant of the P30-4 protein, the P30-5 protein, a variant of the P30-5 protein, the P30-6 protein, a variant of the P30-6 protein, the P30-7 protein, a variant of the P30-7 protein, the P30-8 protein, a variant of the P30-8 protein, the P30-9 protein, a variant of the P30-9 protein, the P30-10 protein, a variant of the P30-10 protein, a P30-11 protein, a variant of the P30-11 protein, the P20-12 protein, and a variant of the P30-12 protein.
An isolated polypeptide selected from the group consisting of the OMP-1 protein, the OMP-1R protein, a variant of the OMP-1R protein, the OMP-1S protein, a variant of the OMP-1S protein, the OMP-1T protein, a variant of the OMP-1T protein, the OMP-1U protein, a variant of the OMP-1U protein, the OMP-1V protein, a variant of the OMP-1V protein, the OMP-1W protein, a variant of the OMP-1W protein, the OMP1X protein, a variant of the OMP-1X protein, the OMP-1Y protein, a variant of the OMP-1Y protein, the OMP-1Z protein, a variant of the OMP-1Z protein, the OMP-1H protein, a variant of the OMP-1H protein.
An antibody which binds to a protein selected from the group consisting of P30, P30a, P30-1, P30-2, P30-3, P30-4, P30-5;
Dependencies are inferred from the claim text.