Anthrax and Small Pox replikins and methods of use
OwnerSamuel Bogoch, Elenore S. Bogochinventors
Life of this patent
Estimating the term…
Abstract
Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.
Claims27
An isolated Bacillus anthracis peptide comprising from 7 to about 50 amino acids including
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An isolated small pox virus peptide comprising from 7 to about 50 amino acids including
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An antibody that specifically binds to a Bacillus anthracis peptide or polypeptide sequence comprising from 7 to about 50 amino acids including (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An antibody cocktail comprising a plurality of antibodies, wherein each of said antibodies specifically binds to a Bacillus anthracis peptide or polypeptide sequence comprising from 7 to about 50 amino acids including (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An antibody that specifically binds to a small pox virus peptide or polypeptide sequence comprising from 7 to about 50 amino acids including (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An antibody cocktail comprising a plurality of antibodies, wherein each of said antibodies specifically binds to a small pox virus peptide or polypeptide sequence comprising from 7 to about 50 amino acids including (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
A method of stimulating the immune system of a subject to produce antibodies to Bacillus anthracis comprising administering an effective amount of at least one Bacillus anthracis peptide comprising from 7 to about 50 amino acids including (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
A method of stimulating the immune system of a subject to produce antibodies to small pox virus comprising administering an effective amount of at least one small pox virus peptide comprising from 7 to about 50 amino acids including (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An antisense nucleic acid molecule complementary to a mRNA encoding a Bacillus anthracis polypeptide comprising a replikin sequence comprising from 7 to about 50 amino acids including
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An antisense nucleic acid molecule complementary to the coding strand of the gene or to the mRNA encoding the Bacillus anthracis Anthrax Lethal Factor Protein pX01-107 peptide, wherein said antisense nucleic acid molecule is complementary to a nucleotide sequence encoding the peptide of SEQ ID NO. 91, SEQ ID NO. 92, SEQ ID NO. 93, SEQ ID NO. 94, SEQ ID NO. 95, SEQ ID NO. 96, SEQ ID NO. 97, SEQ ID NO. 98.
An antisense nucleic acid molecule complementary to a mRNA encoding a Small Pox Virus polypeptide comprising a replikin sequence comprising from 7 to about 50 amino acids including
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An antisense nucleic acid molecule complementary to the coding strand of the gene or to the mRNA encoding the Small Pox Virus Surface Antigen S Precursor Protein, wherein said antisense nucleic acid molecule is complementary to a nucleotide sequence encoding the peptide of SEQ ID NO. 99, SEQ ID NO. 100, SEQ ID NO. 101, SEQ ID NO. 102, or SEQ ID NO. 103.
Dependencies are inferred from the claim text.