Use of dendroaspin as a scaffold for non-dendroaspin domains
OwnerXinjie Lu, Vijay Vir Kakkarinventors
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Abstract
The use of dendroaspin as a scaffold for one or more non-wild-type dendroaspin domains, the dendroaspin scaffold being modified in that the native RGD motif has been deleted or has been replaced by (i) an amino acid sequence having no integrin-binding activity or (ii) an integrin-binding amino acid sequence other than RGD which contains aspartic acid (D) or glutamic acid (E).
Claims56
A polypeptide comprising a dendroaspin scaffold in which the native RGD motif has been deleted or has been replaced by a replacement amino acid sequence which is (i) an amino acid sequence having no integrin-binding activity or (ii) an integrin-binding amino acid sequence and comprising a tripeptide sequence other than RGD containing D or E adjacent to G.
A polypeptide of claim 2(I) or claim 4 in which B is R, K, Q, A, H or N, provided that B-J-Z is not RGD.
A polypeptide of 2(I) in which the integrin-binding amino acid sequence is preceded by the P which is at position 42 of wild type dendroaspin or by an A residue substituted therefor.
Dependencies are inferred from the claim text.