Surface treatment of silicone medical devices with reactive hydrophilic polymers

The method of claim 7, wherein the functionally reactive monomers are selected from the group consisting of glycidyl methacrylate, maleic anhydride, itaconic anhydride, and isocyanomethacrylate.

A silicone medical device including a hydrophilic surface comprising:

• a medical device made from a silicone material, wherein the silicone material comprises monomeric units having reactive functionalities selected from the group consisting of azlactone, carboxylic acid, amine, hydroxy, and epoxy functionalities, and compatible combinations thereof;
• and hydrophilic polymers attached to the medical device wherein the points of attachment are the result of the reaction of isocyanate, hydroxy, amine, carboxylic acid, or ring-opening complementary reactive functionalities or compatible combinations thereof in monomeric units along the hydrophilic reactive polymers with said functionalities on or near the surface of the medical device or the results, wherein in the in the case of the hydroxy or amine complementary reactive functionalities, the silicone material comprises azlactone reactive functionalities and in the case of the carboxylic acid complementary functionality, the silicone material comprises epoxy reactive functionalities, thereby producing a clear, transparent biocompativle coating.

A copolymer comprising 1 to 99 mole percent of a monomeric unit derived from monomers selected from the group consisting of acrylamides, lactams and poly(alklylene oxides), hydroxyalkyl methacrylates, wherein the alkylene or alkyl groups have 1 to 6 carbon atoms, and 1 to 99 mole percent of a monomer selected from the group consisting of the formula:

• 30
• where R1 and R2 independently denote a hydrogen atom or a lower alkyl radical with one to six carbon atoms, and R3 and R4 independently denote alkyl radicals with one to six carbon atoms or a cycloalkyl radicals with 5 or 6 carbon atoms.