Life extension of drosophila by a drug treatment

A method for identifying a molecular alteration in a subject comprising:

• a. administering an inhibitor of histone deacetylase to the subject;
• and
• b. identifying molecular alterations in the subject caused by said inhibitor of histone deacetylase by comparing the presence, level, and/or modification of nucleic acid and/or protein in the subject with the presence, level, and/or modification of nucleic acid and/or protein in a second subject that has not been administered an inhibitor of histone deacetylase, thereby indicative that the inhibitor of histone deacetylase induces a molecular alteration.

A method for identifying a test molecule that induces a molecular alteration in a subject, to which an inhibitor of histone deacetylase has been administered comprising:

• a. administering a test molecule to the subject;
• and
• b. identifying molecular alterations in the subject caused by said test molecule by comparing the presence, level, and/or modification of nucleic acid and/or protein in the subject with the presence, level, and/or modification of nucleic acid and/or protein in a second subject that has been administered an inhibitor of histone deacetylase, but was not administered with the test molecule, a difference in the presence, level, and/or modification of nucleic acid and/or protein thereby indicative that the test molecule induces a molecular alteration.

A method for identifying a molecule that extends the life span of a subject, wherein the subject has an extended life comprising:

• a. administering a test molecule to the subject, to which an inhibitor of histone deacetylase has been administered;
• b. comparing the life span of the subject of a) with a second subject, that has been administered an inhibitor of histone deacetylase and not administered the test molecule, a further extended life span by the subject of a) thereby identifies a molecule that extend the life span of the subject.