Inverse thiazolylamide derivatives

Compounds of the general formula (I):

• 30
• in which
• R1 represents hydrogen, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, amino-(C1-C6)-alkyl or halogeno-(C1-C6)-alkyl,
• R2 and R3 are identical or different and represent hydrogen or represent (C1-C6)-alkyl which is optionally substituted by 1 to 3 substituents selected from the group consisting of (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, halogen, hydroxyl, amino and (C6-C10)-aryl which for its part may be substituted by hydroxyl or (C1-C6)-alkoxy, or
• R2 and R3 together with the nitrogen atom form a 5- or 6-membered saturated heterocycle which may optionally also contain an oxygen atom,
• R4 represents hydrogen, (C1-C6)-acyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl or (C1-C6)-alkoxycarbonyl, or
• R4 represents (C1-C6)-alkyl which may optionally be substituted by 1 to 3 substituents selected from the group consisting of halogen, hydroxyl, (C1-C6)-acyl, (C1-C6)-alkoxy, —(OCH2CH2)nOCH2CH3, where n is 0 or 1, phenoxy, (C6-C10)-aryl and —NR13R14,
• where
• R13 and R14 are identical or different and represent hydrogen, (C1-C6)-acyl, (C1-C6)-alkyl, carbamoyl, mono- or di-(C1-C6)-alkylamino-(C1-C6)alkyl, mono- or di-(C1-C6)-alkyl-aminocarbonyl, (C6-C10)-aryl or (C1-C6)-alkoxycarbonyl, or
• R13 and R14 together with the nitrogen atom form a 5- or 6-membered saturated heterocycle which may optionally contain a further heteroatom from the group consisting of S and O or a radical of the formula —NR15 and which may be substituted by oxo,
• where
• R15 represents hydrogen or (C1-C4)-alkyl,
• R5 represents no substituent, hydrogen, (C1-C6)-alkyl or (C1-C6)-alkanoyl,
• R6 represents phenyl which may optionally be substituted by one to three substituents selected from the group consisting of
• halogen,
• (C6-C10)-aryl which may optionally be substituted by 1 to 3 substituents selected from the group consisting of (C1-C6)-alkanoyl, (C1-C6)-alkoxy, (C -C6)-alkyl, halogen, (C -C6)-alkoxycarbonyl, nitro, halogeno-(C1-C6)-alkyl, halogeno-(C1-C6)-alkoxy, amino, (C1-C6)-alkylthio, hydroxyl, carboxyl, carbamoyl, mono- or di-(C1-C6)-alkylaminocarbonyl, mono- or di-(C1-C6)-alkanoylamino, (C1-C6)-alkoxycarbonylamino, (C1-C6)-alkylsulphoxy, (C1-C6)-alkylsulphonyl, tri-(C1-C6)-alkylsilyloxy, a 3- to 8-membered saturated or unsaturated non-aromatic mono- or bicyclic heterocycle having up to 3 heteroatoms from the group consisting of S, N and O, which is optionally attached via a nitrogen atom, and cyano,
• (C1-C6)-alkoxycarbonyl,
• (C1-C6)-alkylthio,
• hydroxyl,
• carboxyl,
• partially fluorinated (C1-C6)-alkoxy having up to 6 fluorine atoms,
• (C1-C6)-alkyl which may optionally be substituted by a radical of the formula
• 31
• an aromatic heterocycle having up to 3 hetero atoms from the group consisting of S, N and O, which is optionally attached via a nitrogen atom and may optionally be substituted by 1to 3 substituents selected from the group consisting of (C1-C6)-alkanoyl, (C1-C6)-alkoxy, (C1-C6)-alkyl, halogen, (C1-C6)-alkoxycarbonyl, nitro, halogeno-(C1-C6)-alkyl, halogeno-(C1-C6)-alkoxy, amino, (C1-C6)-alkylthio, hydroxyl, carboxyl, carbamoyl, mono- or di-(C1-C6)-alkylaminocarbonyl, mono-or di-(C1-C6)-alkanoylamino, (C1-C6)-alkoxycarbonyl amino, (C1-C6)-alkylsulphoxy, (C1-C6)-alkylsulphonyl, a 3- to 8-membered saturated or unsaturated non-aromatic mono- or bicyclic heterocycle having up to 3 heteroatoms from the group consisting of S, N and O, which is optionally attached via a nitrogen atom, and cyano,
• a 3- to 8-membered saturated or unsaturated non-aromatic mono- or bicyclic heterocycle having up to 3 heteroatoms from the group consisting of S, N and O, which is optionally attached via a nitrogen atom and which may optionally be substituted by 1 to 3 substituents selected from the group consisting of oxo, halogen, hydroxyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkoxycarbonylamino, (C1-C6)-alkyl, halogeno-(C1-C6)-alkyl and hydroxy-(C1-C6)-alkyl,
• and groups of the formulae
• —OR19,
• —NR20R21 or —CO—NR22R23,
• in which
• R19 is phenyl which for its part is optionally substituted by a group of the formula —NR24R25,
• in which
• R24 and R25 are identical or different and represent hydrogen, (C1-C6)-alkyl or (C1-C6)-acyl,
• or
• R19 represents (C1-C6)-alkyl which is optionally mono- to trisubstituted by hydroxyl and/or halogen,
• R20 and R 21 are identical or different and hydrogen, carbamoyl, mono- or di-(C1-C6)-alkylaminocarbonyl, phenyl, (C1-C6)-acyl or (C1-C6)-alkyl, where the (C1-C6)-alkyl mentioned above is optionally substituted by (C1-C6)-alkoxy, (C1-C6)-acyl, by phenyl or by a 5- or 6-membered aromatic heterocycle having up to 3 heteroatoms from the group consisting of S, N and O, where the phenyl mentioned above and the aromatic heterocycle mentioned above are optionally mono- to trisubstituted by identical or different substituents from the group consisting of halogen and hydroxyl, and
• R22 and R23 are identical or different and represent hydrogen or (C1-C6)-alkyl,
• R7 represents hydrogen, (C1-C6)-alkyl or (C1-C6)-alkanoyl,
• R8 represents no substituent, hydrogen or (C1-C6)-alkyl, and
• represents a single or double bond,
• and their salts.