Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
AssigneeNeuroSearch A/S
InventorsBo S. Jensen, Soren-Peter Olsen, Tino D. Jorgensen, Dorte Strobaek, Palle Christophersen
Life of this patent
Estimating the term…
Abstract
The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction. Moreover, the invention relates to a method of screening a chemical compound for inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca).
Claims32
Use of a chemical compound having IKCa inhibitory activity for the manufacture of a medicament for the treatment or alleviation of diseases, disorders or conditions relating to immune dysfunction.
A pharmaceutical composition for use in the treatment or alleviation of diseases, disorders or conditions relating to immune dysfunction, which pharmaceutical composition comprises an effective amount of a chemical compound having IKCa inhibitory activity.
A method for treatment or alleviation of diseases, disorders or conditions relating to immune dysfunction in a living body, said method comprising administering to said living body an effective amount of a chemical compound having IKCa inhibitory activity.
A method of screening a chemical compound for inhibitory activity on an intermediate conductance Ca2+ activated potassium channel (IKCa), which method comprises the steps of
- (i) subjecting an IKCa containing cell to the action of the chemical compound, and
- (ii) monitoring the membrane potential of the IKCa containing cell.
Dependencies are inferred from the claim text.