US 2002/0119966 A1 · Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

Abstract

This invention provides compounds of formula I having the structure 1 wherein: R1 and R2 are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated, acyl, or aroyl; R3, R4 are H, alkyl, cycloalkyl or —CH2-cycloalkyl; R5 is H or alkyl; R6 is H or alkyl; and wherein the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods for using these compounds to treat central nervous system disorders, including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

Claims11

Dependent claims

A compound of the formula:

6
wherein:
R1 and R2 are each independently selected from hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, fluorinated alkyl of 1-6 carbon atoms, —CN, —NH—SO2-alkyl of 1-6 carbon atoms, —SO2—NH-alkyl of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluorinated alkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl;
R3, R4 are each independently hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl or —CH2—C3-C7 cycloalkyl;
R5 is hydrogen or C1-C6 alkyl;
R6 is hydrogen or C1-C6 alkyl;
and
the dashed line indicates an optional double bond;
or a pharmaceutically acceptable salt thereof.

6 more elements

Dependencies are inferred from the claim text.

Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

Life of this patent

Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

Life of this patent

Abstract

Claims11