Novel compositions of cobalamin and related corrinoids, and uses thereof
OwnerWilliam J. Sarill, Thomas F. Brennaninventors
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Abstract
Novel compositions cobalamin and related corrinoids, and uses thereof, are disclosed. The novel compositions include a corrin, a first amino acid having a side chain which includes a basic or positively charged moiety; and a second amino acid with an uncharged side chain which includes at least one heteroatom. The compositions are useful for, inter alia, treatment of cobalamin deficiency.
Claims19
A composition comprising a mixture of:
- (a) a corrin selected from the group consisting of cobalamins and corrinoids;
- (b) a first amino acid having a side chain which includes a basic or positively charged moiety;
- and
- (c) . a second amino acid with an uncharged side chain which includes at least one heteroatom,
- wherein said composition comprises an excess by weight of the corrin relative to at least one of the first amino acid and the second amino acid.
A composition comprising a mixture of:
- (a) a cobalamin;
- (b) a first amino acid selected from the group consisting of lysine, arginine or ornithine;
- and
- (c) a second amino acid selected from the group consisting of glutamine, tyrosine, serine, threonine, tryptophan or asparagine,
- wherein said composition comprises an excess by weight of the cobalamin relative to at least one of the first or second amino acid.
A composition comprising a mixture in a pharmaceutically acceptable carrier of:
- (a) cobalamin;
- (b) lysine, arginine, histidine or ornithine;
- and
- (c) glutamine, tyrosine, serine, threonine, tryptophan or asparagine, in a molar ratio of from about 1:0.1:0.1 to about 1:100:100.
A method of increasing cellular uptake of cobalamin in the cells of a subject, comprising administering to the subject an active amount of a composition comprising a mixture of:
- (a) cobalamin;
- (b) lysine, arginine, histidine or ornithine;
- and
- (c) glutamine, tyrosine, serine, threonine, tryptophan or asparagine, in a molar ratio of from about 1:0.1:0.1 to about 1:100:100, such that cellular uptake of cobalamin in the cells of the subject is increased.
Dependencies are inferred from the claim text.