Composition & method for reducing adenosine levels with a ubiquinone and optionally a dehydroepiandrosterone

A pharmaceutical or veterinary composition, comprising a carrier or diluent, and an active agent selected from

• a dehydroepiandrosterone, or pharmaceutically or veterinarily acceptable salts thereof, the dehydroepiandrosterone having the chemical formula
• 7
• wherein the broken line represents a single or a double bond;
• R is hydrogen or a halogen;
• the H at position 5 is present in the alpha or beta configuration or the compound of chemical formula I comprises a racemic mixture of both configurations;
• and R1 is hydrogen or SO2OM, wherein M is selected from H, Na, sulfatide
• 8
• or phosphatide
• 9
• wherein R2 and R3, which may be the same or different, are straight or branched (C1-C14) alkyl or glucuronide
• 10
• and/or a ubiquinone or pharmaceutically or veterinarily acceptable salt thereof, wherein the ubiquinone has the chemical formula
• 11
• wherein n is 1 to 12, the agent being present in an amount effective for altering levels of, or sensitivity to, adenosine or adenosine receptors, adenosine in a subject's tissue (s), or treating bronchoconstriction, lung inflammation or allergies or a disease associated with either of them.