Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity
AssigneeProvincia Italiana Della Congregazione Dei Figli Dell'Immacolata Concezione—Instituto Dermopatico Dell'Immacolata
InventorsAntonio Facchiano, Francesco Facchiano, Angelo Facchiano
Life of this patent
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Abstract
A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. The molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC) The molecule is also able to inhibit in vivo angiogenesis CD1 mice.
Claims11
1) Peptide having the following primary structure:
- Asp-Pro-His-Lle-Lys-Leu-Gln-Leu-Gln-Ala-Glu
2) peptide having sequence-identity of at least 60% with the following sequence:
- Asp-Pro-His-Lle-Lys-Leu-Gln-Leu-Gln-Ala-Glu
3) Peptide having electric-charge homology or hydrophilia or hydrophobicity or solvent-exposure rate or three-dimensional conformation of at least 60% with the following sequence:
- Asp-Pro-His-Lle-Lys-Leu-Gln-Leu-Gln-Ala-Glu
4) Peptidic or non-peptidic molecules showing conformational similarity or functional-group disposition similarity, of at least 60% with the following sequence:
- Asp-Pro-His-Lle-Lys-Leu-Gln-Leu-Gln-Ala-Glu
Dependencies are inferred from the claim text.