Inhibitors of IAPP fibril formation and uses thereof
AssigneeThe Governing Counsel of the University of Toronto
InventorPaul Fraser
Life of this patent
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Abstract
New antifibrillogenic agents and compositions containing same, methods of using the antifibrillogenic agents and compositions for inhibiting amyloid fibril formation, and effective therapeutics for preventing or delaying the progression of, e g., Alzheimer's disease and diabetes.
Claims55
An antifibrillogenic agent for inhibiting amyloidosis and/or for cytoprotection, comprising a peptide selected from the group consisting of ATQRLANFLVIISSSSNNFGAILSSTN (SEQ ID NO. 1), ATQRLANFLVHSS (SEQ ID NO. 2), NVGSNTY (SEQ ID NO. 3), SSNNFGAILSSTN (SEQ ID NO. 4), ATQRLA (SEQ ID NO. 5), LANFLV (SEQ ID NO. 6), ANFLVH (SEQ ID NO. 7), NFLVHS (SEQ ID NO. 8), FLVHSS (SEQ ID NO. 9), SSNNFG (SEQ ID NO. 10), SNNFGA (SEQ ID NO. 11), NNFGAI (SEQ ID NO. 12), FGAILS (SEQ ID NO. 13), GAILSS (SEQ ID NO. 14), AILSST (SEQ ID NO. 15), ILSSTN (SEQ ID NO. 16), NVGSNT (SEQ ID NO. 17), and VGSNTY (SEQ ID NO. 18), an isomer thereof, a retro or a retro-inverso isomer thereof, a peptidomimetic thereof or a salt thereof.
A peptide for inhibiting amyloidosis and/or for cytoprotection, said peptide comprising a sequence selected from the group consisting of ATQRLA (SEQ ID NO. 5), LANFLV (SEQ ID NO. 6), ANFLVH (SEQ ID NO. 7), NFLVHS (SEQ ID NO. 8), FLVHSS (SEQ ID NO. 9), SSNNFG (SEQ ID NO. 10), SNNFGA (SEQ ID NO. 11), NNFGAI (SEQ ID NO. 12), FGAILS (SEQ ID NO. 13), GAILSS (SEQ ID NO. 14), AILSST (SEQ ID NO. 15), ILSSTN (SEQ ID NO. 16), NVGSNT (SEQ ID NO. 17), and VGSNTY (SEQ ID NO. 18);
- an isomer thereof, a retro or a retro-inverso isomer thereof, a peptidomimetic thereof or a salt thereof.
A peptide, an isomer thereof, a retro or a retro-inverso isomer thereof, a peptidomimetic thereof, or a salt thereof, for inhibiting amyloidosis and/or for cytoprotection, wherein said peptide binds to a sequence selected from the group consisting of ATQRLANFLVHSSSSNNFGAILSSTN (SEQ ID NO. 1), ATQRLANFLVHSS (SEQ ID NO. 2), NVGSNTY (SEQ ID NO. 3), SSNNFGAILSSTN (SEQ ID NO. 4), ATQRLA (SEQ ID NO. 5), LANFLV (SEQ ID NO. 6), ANFLVH (SEQ ID NO. 7), NFLVHS (SEQ ID NO. 8), FLVHSS (SEQ ID NO. 9), SSNNFG (SEQ ID NO. 10), SNNFGA (SEQ ID NO. 11), NNFGAI (SEQ ID NO. 12), FGAILS (SEQ ID NO. 13), GAILSS (SEQ ID NO. 14), AILSST (SEQ ID NO. 15), ILSSTN (SEQ ID NO. 16), NVGSNT (SEQ ID NO. 17), and VGSNTY (SEQ ID NO. 18), whereupon said binding, fibril formation and/or amyloidosis are prevented.
Dependencies are inferred from the claim text.