Peptides for inhibition of HIV infection
AssigneeKorea Institute of Science and Technology
InventorsYeon Gyu Yu, Key-Sun Kim, Bong-Suk Jin
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Abstract
The present invention relates to peptides that can inhibit the infection of HIV, and more particularly, to peptides consisting of less than 30 amino acids which can introduce a helix capping motif into a peptide derived from C-terminal helical region (its 628-646th amino acid region) of gp41, an envelope glycoprotein of HIV, as well as consisting of the symmetrical bivalent peptide through the introduction of a branched amino acid, Fmoc-Lys(Fmoc)-OH at C-terminus of its peptide, and induce a more stable helical structure thus inhibiting the infection of HIV.
Claims4
Peptides that can inhibit the infection of HIV, wherein each of said peptide involves 19 amino acids(628th-646thregion) of C-terminal helical region of gp41, and helix-capping motifs appended at the ends of the peptide.
Dependencies are inferred from the claim text.