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US 2002/0119910 A1Published application
Compounds and compositions for delivering active agents
AssigneeEmisphere Technologies, Inc.
InventorsAndrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, Koc-Kan Ho, David Gschneidner, Eugene N. Barantsevich
Life of this patent
Estimating the term…
Abstract
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Claims31
A composition comprising:
- (A) at least one active agent;
- and
- (B) at least one carrier selected from the group consisting of
- 5 9 1 6-N-(3,5-dichloro-2-hydroxybenzoyl)aminocaproic acid 10 2 8(2-aminobenzoylamino)caprylic acid 11 3 8(2-trifluoromethoxy)benzoylamino caprylic acid 12 4 N-(2-hydroxybenzoyl)isonipecotic acid 13 5 4-[4-(2-aminobenzoylamino)phenyl]butyrylhydroxamic acid 14 6 4-(4-pentafluorobenzoyl)aminophenyl)butyric acid 15 7 4-(4-(3-anisoyl)aminophenyl)butyric acid 16 8 8-(3-anisoyl)aminocaprylic acid 17 10 4-(4-(2-nitrobenzenesulfonyl)aminophenyl)butyric acid 18 11 8-(2-nitrobenzenesulfonyl)aminocaprylic acid 19 12 6-(4-(salicyloyl)aminophenyl)hexanoic acid 20 13 8-(2-methoxylbenzoyl)amino caprylic acid 21 14 2-[4-Salicyloylamino)phenyl]ethyl methyl sulfone 22 15 1-Salicyloyl-2-succinyl hydrazide 23 16 3-(4-(2,5-dimethoxycinnamoyl)aminophenyl)propionic acid 24 17 4-(4-(2,5-dimethoxycinnamoyl)aminophenyl)butyric acid 25 18 1-salicyloyl-2-glutaryl hydrazide 26 19 Succinyl-4-aminosalicylic acid 27 20 8-(Phenoxyacetylamino)caprylic acid 28 21 8-(2-pyrazinecarbonyl)aminocaprylic acid 29 22 4-(4-(2-pyrazinecarbonyl)aminophenyl)butyric acid 30 23 6-(4-(N-2-Nitrobenzoyl)aminophenyl)hexanoic acid 31 24 6-(4-(N-2-aminobenzoyl)aminophenyl)hexanoic acid 32 25 4-(4-(2-(3-carboxyl)pyrazinecarboxyl)aminophenyl)butyric acid 33 26 4(2-Nitrobenzoyl)aminophenylsuccinic acid 34 27 8-(2-(trifluoromethoxy)benzoyl)aminocaprylic acid 35 28 36 29 8-(Benzylcarbonylamino)caprylic acid 37 30 8-(phenylcarbonylamino)caprylic acid 38 31 2-[4-(2-Methoxybenzoylamino)phenyl]ethyl H2PO4 39 32 1-salicyloyl-2-suberyl hydrazide 40 33 4-(4-benzyloxycarbonylaminophenyl)butyric acid 41 34 4-(4-(2-hydroxynicotinoyl)aminophenyl)butyric acid 42 36 4-(4-phenyloxycarbonylaminophenyl)butyric acid 43 37 3-(2-methoxybenzoylamino)-1-propanol 44 38 8-(2-Hydroxynicotinoyl)aminocaprylic acid 45 39 6-(2-methoxybenzoyl)amino nicotinic acid 46 40 salicyloylglycine 47 41 4-(1-(2-pyrimidyl)piperazinoyl)butyric acid 48 42 8-(chromone-3-carbonyl)aminocaprylic acid 49 43 8-(vinylbenzoyl)aminocaprylic acid 50 44 4-(4-(chromone-3-carbonyl)aminophenyl)butyric acid 51 45 8-cinnamoylaminocaprylic acid 52 46 5-(N-salicyloylamino)valeric acid 53 47 9-(2-hydroxybenzamido)nonanic acid 54 48 N-(4-salicyloylamino)-6-caproic acid 55 49 4′-flavonic acid 56 50 11-cinnamoylaminoundecanoic acid 57 51 4-octanoylamino-3-hydroxybenzoic acid 58 52 (3Phenyl2,3dihydroxypropanoyl)8aminocaprylic acid 59 53 8-[N-(3-coumarincarbonyl)]aminocaprylic acid 60 54 8-[N-(4-chlorobenzoyl)]aminocaprylic acid 61 55 8-[N-3-fluorobenzoyl)]aminocaprylic acid 62 56 8-(N-2,5-Dihydroxybenzoyl)aminocaprylic acid 63 57 8-(N-2,3-Dimethoxybenzoyl)aminocaprylic acid 64 58 8-(N-2,4-Dihydroxybenzoyl)aminocaprylic acid 65 59 8-(N-2,5-Dimethoxybenzoyl)aminocaprylic acid 66 60 8-(N-3,5-Diacetyloxybenzoyl)aminocaprylic acid 67 61 8-(N-4-Hydroxybenzoyl)aminocaprylic acid (dimer) 68 62 8-(N-2,4-Dihydroxybenzoyl)aminocaprylic acid 69 63 10-(N-2-Methoxyanilino)sebalic acid 70 65 2-Methoxybenzenaminodecanoic acid 71 66 8-(N-benzoyl)aminocaprylic acid 72 68 8-[N-(4-fluorobenzoyl)]aminocaprylic acid 73 69 8-[N-(3-bromobenzoyl)]aminocaprylic acid 74 70 8-(4-(1,2-dihydroxyethyl)benzoyl)aminocaprylic acid 75 71 8-[N-(4-bromobenzoyl)]aminocaprylic acid 76 72 8-[N-(4-iodobenzoyl)]aminocaprylic acid 77 73 4-{4-[N-(2-iodoenzoyl)aminophenyl]}butyric acid 78 74 4-{4-[N-(1-hydroxy-2-naphthoyl)aminophenyl]}butyric acid 79 75 4-(4-(2,4-dimethoxylbenzoyl)aminophenyl)butyric acid 80 76 4-(o-anisoyl)aminophenylacetic acid 81 77 3-[4-(2,4-dimethoxybenzoyl)aminophenyl]propionic acid 82 78 4-{4-[N-(4-iodobenzoyl)]aminophenyl}butyric acid 83 80 4-{[N-2-bromobenzoyl)]aminophenyl}butyric acid 84 81 4-{4-[N-3-bromobenzoyl)aminophenyl]}butyric acid 85 82 8-(N-3,5 Dihydroxybenzoyl)aminocaprylic acid 86 83 8-(N-3,5-Dimethoxy 4-hydroxybenzoyl)aminocaprylic acid 87 84 8-(N-2-6-Dimethoxybenzoyl)aminocaprylic acid 88 85 4-{4-[N-(4-bromobenzoyl)aminophenyl]}butyric acid 89 86 8-(2-hydroxy-4-chlorobenzoyl)aminocaprylic acid 90 87 8-(N-2,6-Dihydroxybenzoyl)aminocaprylic acid 91 88 8-(N-2-Hydroxy6-methoxybenzoyl)aminocaprylic acid 92 89 8-(5-chloro-o-anisoyl)aminocaprylic acid 93 90 4-(4-(2,3-dimethoxybenzoyl)aminophenyl)butyric acid 94 91 4-(4-(5-chloro-o-anisoyl)aminophenyl)butyric acid 95 92 4-(4-(4-chloro-o-anisoyl)aminophenyl)butyric acid 96 93 8-(4-chloro-o-anisoyl)aminocaprylic acid 97 94 3-(4-(2,5-dimethoxybenzoyl)aminophenyl)propionic acid 98 95 4-{N-[4-(3-iodobenzoyl)aminophenyl]}butyric acid 99 96 7-cinnamoylaminoheptanoic acid 100 97 8-N-(3-iodobenzoyl)aminocaprylic acid 101 98 8-N-(4-methoxy-3-nitrobenzoyl)aminocaprylic acid 102 99 8-N-(2-methoxy-4-nitrobenzoyl)aminocaprylic acid 103 100 4-{N-[4-(2-methoxy-2-nitrobenzoyl)aminophenyl]}butyric acid 104 101 4-(4-(2,5-dimethyoxybenzoyl)aminophenyl)butyric acid 105 103 3-Indolebutyric acid 106 104 107 105 108 106 109 108 4-[4-N-(4-methoxy-3-nitrobenzoyl)aminophenyl]butyric acid 110 110 8-(N-2-hydroxy-5-iodobenzoyl)aminocaprylic acid 111 112 8-(N-2-hydroxy-4-nitrobenzoyl)aminocaprylic acid 112 113 4-[-N-(2-hydroxy-4-bromobenzoyl)aminophenyl]butyric acid 113 114 8-(N-2,3-Dihydroxybenzoyl)aminocaprylic acid 114 115 8-(N-3-methylsalicyloyl)aminocaprylic acid 115 116 8-(N-5-methylsalicyloyl)aminocaprylic acid 116 118 4-(4-(2-chloro-5-nitrobenzoyl)aminophenyl)butyric acid 117 119 4-{-[N-(2-hydroxy-5-iodobenzoyl)]aminophenyl}butyric acid 118 120 N-2-nitrophenyl-N′-(8-octanoic acid) urea 119 121 N-(2-methoxy-5-nitrophenyl) sebecoyl amide acid 120 123 8-[N-(2-acetoxy-3,5-dibromobenzoyl)]aminocaprylic acid 121 124 8-N-(2-chloro-6-fluorobenzoyl)aminocaprylic acid 122 125 123 126 8-N-(4-hydroxy-3-nitrobenzoyl)caprylic acid 124 127 4-(4-salicyloylaminophenyl)-4-oxobutyric acid 125 128 12-cinnamoyldodecanoic acid 126 129 4-{4-[N-(3-hydroxy-2-napthoyl)aminophenyl]}butyric acid 127 130 8-(4-chloro-3-nitrobenzoyl)aminocaprylic acid 128 131 8-(2-chloronicotinoyl)aminocaprylic acid 129 132 8-(2-chloro-5-nitrobenzoyl)aminocaprylic acid 130 133 4-(4-phthalimidophenyl)butyric acid 131 134 4-{4-[N-(3-hydroxy-2-napthoyl)aminophenyl]}propanoic acid 132 135 3-(4-(2,6-dimethoxybenzoyl)aminophenyl)propionic acid 133 137 8-(N-2-chloro-4-fluorobenzoyl)aminocaprylic acid 134 138 8-(2(1,2-dihydroisoindole-1-one))octanoic acid 135 139 8-(N-1-hyroxy-2-naphthoyl)aminocaprylic acid 136 140 8-(phthalimido)caprylic acid 137 142 6-(anisoyl)aminocaproic acid 138 143 4-(4-(4-chloro-3-nitrobenzoyl)aminophenyl)butyric acid 139 144 11-N-(1-hydroxy-2-naphthoyl)aminoundecanoic acid 140 145 Bis(N-2carboxylphenyl-N-(N′-8-octanoic acid)ureal) oxalyl diamide 141 146 2-[2-N-(2-chlorobenzoyl)aminoethoxy]ethanol 142 147 2-[2-N-(4-chlorobenzoyl)aminoethoxy]ethanol 143 148 4-(2-methoxybenzoyl)amino 3-carboxysulfoxide 144 149 4-(2-methoxybenzoyl)amino 3-carboxypropylsulfone 145 150 4-(4-(3-hydroxyphthalimido)phenyl)butyric acid 146 151 2-[2-N-(2-methoxybenzoyl)aminoethoxy)]ethanol 147 152 2-[2-N-(3-chlorobenzoyl)aminoethoxy)]ethanol 148 153 Bis(N-2-carboxyphenyl-N-(N′-3(4-aminophenyl)propionic acid)ureal) oxaylyl diamide 149 154 trans-4-(2-aminobenzamidomethyl)cyclohexamecarboxylic acid 150 155 11-N-(3,5-dichloro-2-hydroxybenzoyl)aminoundecanoic acid 151 156 2-[N-(2-bromobenzoyl)aminoethoxy]ethanol 152 157 7-N-(3,5-dichloro-2-hydroxybenzoyl)aminoheptanoic acid 153 158 N-[3,5-dichloro-2-hydroxybenzoyl-4(4-aminophenyl)]butyric acid 154 159 trans-4-(N-salicyloylaminomethyl)cyclohexane carboxylic acid 155 160 N-[3,5-dichloro-2-hydroxybenzoyl-3-(4-aminophenyl)]propionic acid 156 161 12-N-(3,5-dichloro-2-hydroxybenzoyl)aminododecanoic acid 157 162 N-(2-hydroxy-4-carboxy)-6-heptenamide 158 163 N-(2-bromobenzoyl)morpholine 159 164 8-N-cyclohexanoylaminocaprylic acid 160 165 2-[N-(2-iodobenzoyl)aminoethoxy]ethanol 161 166 5-(4-chloro-2-hydroxyanilinocarbonyl)valeric acid 162 167 8-(2-hydroxyphenoxy)-aminocaprylic acid 163 168 N-Salicoyl-5-(3-aminophenyl)valeric acid 164 169 4-(4-(2-ethoxylbenzoyl)aminophenyl)butyric acid 165 170 9-[2-(3-hydroxy)pyridylaminocarbonyl]nonanic acid 166 171 7-(2-hydroxyphenoxyacetyl)aminocaprylic acid 167 172 2-[N-(2-hydroxybenzoylamino)ethoxy]ethanol 168 173 4-[N-(3,5-dichloro-2-hydroxybenzoyl)]aminophenylacetic acid 169 174 8-(2-hydroxy-5-chloroanilinocarbonyl)octanoic acid 170 175 N-salicoyl-5-(4-aminophenyl)valeric acid 171 176 9-(2-hydroxy-5-methylanilinocarbonyl)nonanoic acid 172 177 5-(2-hydroxy-5-methylanilinocarbonyl)valeric acid 173 178 8-(pentafluorobenzoyl)aminocaprylic acid 174 179 3-(3-(salicyloyl)aminophenyl)propionic acid 175 180 8-(2-ethoxybenzoyl)aminocaprylic acid 176 181 4-(4-(2-Dimethylamino benzoic)aminophenyl)butyric acid 177 182 8-(3-Phenoxylpropionylamino)caprylic acid 178 183 4-(salicyloyl)aminophenylethyltetrazole 179 184 8(-(4(N-Saliciloyl-4aminophenyl)butyric)aminocaprylic acid [sic] 180 185 4-(4-(N-(2-Fluorocinnamoyl))aminophenyl) butyric 181 186 4-(4-(N-8(N-Salicyloyl)aminocaprylic)aminiphenyl)butyric acid 182 187 8-(p-anisoyl)aminocaprylic acid 183 188 8-(4-Hydroxybenzoyl)aminocaprylic acid 184 189 8-(3-Hydroxybenzoyl)aminocaprylic acid 185 190 8-(3,4,5-Trimethoxybenzoyl)aminocaprylic acid 186 191 8-(N-4-Methylsalicyloyl)aminocaprillic acid[sic] 187 192 N-10-(2-hydroxy-5-nitroanilino)decanoic acid 188 193 4-(4-(2-chloronicotinoyl)aminophenyl)butyric acid
- and a salt of any of the foregoing.
2 more elements
A compound selected from the group consisting of
- 6 189 1 6-N-(3,5-dichloro-2-hydroxybenzoyl)aminocaproic acid 190 2 8(2-aminobenzoylamino)caprylic acid 191 3 8(2-trifluoromethoxy)benzoylamino caprylic acid 192 4 N-(2-hydroxybenzoyl)isonipecotic acid 193 5 4-[4-(2-aminobenzoylamino)phenyl]butyrylhydroxamic acid 194 6 4-(4-pentafluorobenzoyl)aminophenyl)butyric acid 195 7 4-(4-(3-anisoyl)aminophenyl)butyric acid 196 8 8-(3-anisoyl)aminocaprylic acid 197 10 4-(4-(2-nitrobenzenesulfonyl)aminophenyl)butyric acid 198 11 8-(2-nitrobenzenesulfonyl)aminocaprylic acid 199 12 6-(4-salicyloyl)aminophenyl)hexanoic acid 200 13 8-(2-methoxylbenzoyl)amino caprylic acid 201 14 2-[4-Salicyloylamino)phenyl]ethyl methyl sulfone 202 15 1-Salicyloyl-2-succinyl hydrazide 203 16 3-(4-(2,5-dimethoxycinnamoyl)aminophenyl)propionic acid 204 17 4-(4-(2,5-dimethoxycinnamoyl)aminophenyl)butyric acid 205 18 1-salicyloyl-2-glutaryl hydrazide 206 19 Succinyl-4-aminosalicylic acid 207 20 8-(Phenoxyacetylamino)caprylic acid 208 21 8-(2-pyrazinecarbonyl)aminocaprylic acid 209 22 4-(4-(2-pyrazinecarbonyl)aminophenyl)butyric acid 210 23 6-(4-(N-2-Nitrobenzoyl)aminophenyl)hexanoic acid 211 24 6-(4-(N-2-aminobenzoyl)aminophenyl)hexanoic acid 212 25 4-(4-(2-(3-carboxyl)pyrazinecarboxyl)aminophenyl)butyric acid 213 26 4(2-Nitrobenzoyl)aminophenylsuccinic acid 214 27 8-(2-trifluoromethoxy)benzoyl)aminocaprylic acid 215 28 216 29 8-(Benzylcarbonylamino)caprylic acid 217 30 8-(phenylcarbonylamino)caprylic acid 218 31 2-[4-(2-Methoxybenzoylamino)phenyl]ethyl H2PO4 219 32 1-salicyloyl-2-suberyl hydrazide 220 33 4-(4-benzyloxycarbonylaminophenyl)butyric acid 221 34 4-(4-(2-hydroxynicotinoyl)aminophenyl)butyric acid 222 36 4-(4-phenyloxycarbonylaminophenyl)butyric acid 223 37 3-(2-methoxybenzoylamino)-1-propanol 224 38 8-(2-Hydroxynicotinoyl)aminocaprylic acid 225 39 6-(2-methoxybenzoyl)amino nicotinic acid 226 40 salicyloylglycine 227 41 4-(1-(2-pyrimidyl)piperazinoyl)butyric acid 228 42 8-(chromone-3-carbonyl)aminocaprylic acid 229 43 8-(vinylbenzoyl)aminocaprylic acid 230 44 4-(4-(chromone-3-carbonyl)aminophenyl)butyric acid 231 45 8-cinnamoylaminocaprylic acid 232 46 5-(N-salicyloylamino)valeric acid 233 47 9-(2-hydroxybenzamido)nonanic acid 234 48 N-(4-salicyloylamino)-6-caproic acid 235 49 4′-flavonic acid 236 50 11-cinnamoylaminoundecanoic acid 237 51 4-octanoylamino-3-hydroxybenzoic acid 238 52 (3Phenyl2,3dihydroxypropanoyl)8aminocaprylic acid 239 53 8-[N-(3-coumarincarbonyl)]aminocaprylic acid 240 54 8-[N-(4-chlorobenzoyl)]aminocaprylic acid 241 55 8-[N-3-fluorobenzoyl)]aminocaprylic acid 242 56 8-(N-2,5-Dihydroxybenzoyl)aminocaprylic acid 243 57 8-(N-2,3-Dimethoxybenzoyl)aminocaprylic acid 244 58 8-(N-2,4-Dihydroxybenzoyl)aminocaprylic acid 245 59 8-(N-2,5-Dimethoxybenzoyl)aminocaprylic acid 246 60 8-(N-3,5-Diacetyloxybenzoyl)aminocaprylic acid 247 61 8-(N-4-Hydroxybenzoyl)aminocaprylic acid (dimer) 248 62 8-(N-2,4-Dihydroxybenzoyl)aminocaprylic acid 249 63 10-(N-2-Methoxyanilino)sebalic acid 250 65 2-Methoxybenzenaminodecanoic acid 251 66 8-(N-benzoyl)aminocaprylic acid 252 68 8-[N-(4-fluorobenzoyl)]aminocaprylic acid 253 69 8-[N-(3-bromobenzoyl)]aminocaprylic acid 254 70 8-(4-(1,2-dihydroxyethyl)benzoyl)aminocaprylic acid 255 71 8-[N-(4-bromobenzoyl)]aminocaprylic acid 256 72 8-[N-(4-iodobenzoyl)]aminocaprylic acid 257 73 4-{4-[N-(2-iodobenzoyl)aminophenyl]}butyric acid 258 74 4-{4-[N-(1-hydroxy-2-naphthoyl)aminophenyl]}butyric acid 259 75 4-(4-(2,4-dimethoxylbenzoyl)aminophenyl)butyric acid 260 76 4-(o-anisoyl)aminophenylacetic acid 261 77 3-[4-(2,4-dimethoxybenzoyl) aminophenyl] propionic acid 262 78 4-{4-[N-(4-iodobenzoyl)] aminophenyl} butyric acid 263 80 4-{4-[N-2-bromobenzoyl)] aminophenyl} butyric acid 264 81 4{4-[N-3-bromobenzoyl) aminophenyl]} butyric acid 265 82 8-(N-3,5 Dihydroxybenzoyl)aminocaprylic acid 266 83 8-(N-3,5-Dimethoxy 4-hydroxybenzoyl)aminocaprylic acid 267 84 8-(N-2-6-Dimethoxybenzoyl)aminocaprylic acid 268 85 4-{[N-(4-bromobenzoyl)aminophenyl]}butyric acid 269 86 8-(2-hydroxy-4-chlorobenzoyl)aminocaprylic acid 270 87 8-(N-2,6-Dihydroxybenzoyl)aminocaprylic acid 271 88 8-(N-2-Hydroxy6-methoxybenzoyl)aminocaprylic acid 272 89 8-(5-chloro-o-anisoyl)aminocaprylic acid 273 90 4-(2-(2,3-dimethoxybenzoyl)aminophenyl)butyric acid 274 91 4-(4-(5-chloro-o-anisoyl)aminophenyl)butyric acid 275 92 4-(4-(4-chloro-o-anisoyl)aminophenyl)butyric acid 276 93 8-(4-chloro-o-anisoyl)aminocaprylic acid 277 94 3-(4-(2,5-dimethoxybenzoyl)aminophenyl)propionic acid 278 95 4-{N-[4-(3-iodobenzoyl)aminophenyl]}butyric acid 279 96 7-cinnamoylaminoheptanoic acid 280 97 8-N-(3-iodobenzoyl)aminocaprylic acid 281 98 8-N-(4-methoxy-3-nitrobenzoyl)aminocaprylic acid 282 99 8-N-(2-methoxy-4-nitrobenzoyl)aminocaprylic acid 283 100 4-{N-[4-(2-methoxy-4-nitrobenzoyl)aminophenyl]}butyric acid 284 101 4-(4-(2,5-dimethoxybenzoyl)aminophenyl)butyric acid 285 104 286 105 287 106 288 107 4-(4-(2,6-dimethoxybenzoyl)aminophenylbutyric acid 289 108 4-[4-N-(4-methoxy-3-nitrobenzoyl)aminophenyl]butyric acid 290 110 8-(N-2-hydroxy-5-iodobenzoyl)aminocaprylic acid 291 112 8-(N-2-hydroxy-4-nitrobenzoyl)aminocaprylic acid 292 113 4-[-N-(2-hydroxy-4-bromobenzoyl)aminophenyl]butyric acid 293 114 8-(N-2,3-Dihydroxybenzoyl)aminocaprylic acid 294 115 8-(N-3-methylsalicyloyl)aminocaprylic acid 295 116 8-(N-5-methylsalicyloyl)aminocaprylic acid 296 118 4-(4-(2-chloro-5-nitrobenzoyl)aminophenyl)butyric acid 297 119 4-{-[N-(2-hydroxy-5-iodobenzoyl)]aminophenyl}butyric acid 298 120 N-2-nitrophenyl-N′-(8-octanoic acid) urea 299 121 N-(2-methoxy-5-nitrophenyl) sebecoyl amide acid 300 123 8-[N-(2-acetoxy-3,5-dibromobenzoyl)]aminocaprylic acid 301 124 8-N-(2-chloro-6-fluorobenzoyl)aminocaprylic acid 302 125 303 126 8-N-(4-hydroxy-3-nitrobenzoyl)caprylic acid 304 127 4-(4-Salicyloylaminophenyl)-4-oxobutyric acid 305 128 12-cinnamoyldodecanoic acid 306 129 4-{4-[N-(3-hydroxy-2-napthoyl)aminophenyl]}butyric acid 307 130 8-(4-chloro-3-nitrobenzoyl)aminocaprylic acid 308 131 8-(2-chloronicotinoyl)aminocaprylic acid 309 132 8-(2-chloro-5-nitrobenzoyl)aminocaprylic acid 310 133 4-(4-phthalimidophenyl)butyric acid 311 134 4-{4-[N-(3-hydroxy-2-napthoyl)aminophenyl]}propanoic acid 312 135 3-(4-(2,6-dimethoxybenzoyl)aminophenyl)propionic acid 313 137 8-(N-2-chloro-4-fluorobenzoyl)aminocaprylic acid 314 138 8-(2-(1,2-dihydroisoindole-1-one))octanoic acid 315 139 8-(N-1-hydroxy-2-naphthoyl)aminocaprylic acid 316 140 8-(phthalimido)caprylic acid 317 142 6-(anisoyl)aminocaproic acid 318 143 4-(4-(4-chloro-3-nitrobenzoyl)aminophenyl)butyric acid 319 144 11-N-(1-hydroxy-2-naphthoyl)aminoundecanoic acid 320 145 Bis(N-2carboxylphenyl-N-(N′-8-octanoic acid)ureal)oxalyl diamide 321 146 2-[2-N-(2-chlorobenzoyl)aminoethoxy]ethanol 322 147 2-[2-N-(4-chlorobenzoyl)aminoethoxy]ethanol 323 148 4-(2-methoxybenzoyl)amino 3-carboxysulfoxide 324 149 4-(2-methoxybenzoyl)amino 3-carboxypropylsulfone 325 150 4-(4-(3-hydroxyphthalimido)phenyl)butyric acid 326 151 2-[2-N-(2-methoxybenzoyl)aminoethoxy)]ethanol 327 152 2-[2-N-(3-chlorobenzoyl)aminoethoxy)]ethanol 328 153 Bis(N-2-carboxyphenyl-N-(N′-3(4-aminophenyl)propionic acid)ureal)oxaylyl diamide 329 154 trans-4-(2-aminobenzamidomethyl)cyclohexamecarboxylic acid 330 155 11-N-(3,5-dichloro-2-hydroxybenzoyl)aminoundecanoic acid 331 156 2-[N-(2-bromobenzoyl)aminoethoxy]ethanol 332 157 7-N-(3,5-dichloro-2-hydroxybenzoyl)aminoheptanoic acid 333 158 N-[3,5-dichloro-2-hydroxybenzoyl-4(4-aminophenyl)]butyric acid 334 159 trans-4-(N-salicyloylaminomethyl)cyclohexane carboxylic acid 335 160 N-[3,5-dichloro-2-hydroxybenzoyl-3-(4-aminophenyl)]propionic acid 336 161 12-N-(3,5-dichloro-2-hydroxybenzoyl)aminododecanoic acid 337 162 N-(2-hydroxy-4-carboxy)-6-heptenamide 338 163 N-(2-bromobenzoyl)morpholine 339 164 8-N-cyclohexanoylaminocaprylic acid 340 165 2-[N-(2-iodobenzoyl)aminoethoxy]ethanol 341 166 5-(4-chloro-2-hydroxyanilinocarbonyl)valeric acid 342 167 8-(2-hydroxyphenoxy)-aminocaprylic acid 343 168 N-Salicoyl-5-(3-aminophenyl)valeric acid 344 169 4-(4-(2-ethoxylbenzoyl)aminophenyl)butyric acid 345 170 9-[2-(3-hydroxy)pyridylaminocarbonyl] nonanic acid 346 171 7-(2-hydroxyphenoxyacetyl)aminocaprylic acid 347 172 2-[N-(2-hydroxybenzoylamino)ethoxy]ethanol 348 173 4-[N-(3,5-dichloro-2-hydroxybenzoyl)]aminophenylacetic acid 349 174 8-(2-hydroxy-5-chloroanilinocarbonyl)octanoic acid 350 175 N-salicoyl-5-(4-aminophenyl)valeric acid 351 176 9-(2-hydroxy-5-methylanilinocarbonyl)nonanoic acid 352 177 5-(2-hydroxy-5-methylanilinocarbonyl)valeric acid 353 178 8-(pentafluorobenzoyl)aminocaprylic acid 354 179 3-(3-(salicyloyl)aminophenyl)propionic acid 355 180 8-(2-ethoxybenzoyl)aminocaprylic acid 356 181 4-(4-(2-Dimethylamino benzoic)aminophenyl)butyric acid 357 182 8-(3-Phenoxylpropionylamino)caprylic acid 358 183 4-(Salicyloyl)aminophenylethyltetrazole 359 184 8(-(4(N-Saliciloyl-4aminophenyl)butyric)aminocaprylic acid [sic] 360 185 4-(4-(N-(2-Fluorocinnamoyl))aminophenyl) butyric 361 186 4-(4-(N-8(N-Salicyloyl)aminocaprylic)aminophenyl)butyric acid 362 187 8-(p-anisoyl)aminocaprylic acid 363 188 8-(4-Hydroxybenzoyl)aminocaprylic acid 364 189 8-(3-Hydroxybenzoyl)aminocaprylic acid 365 190 8-(3,4,5-Trimethoxybenzoyl)aminocaprylic acid 366 191 8-(N-4-Methylsalicyloyl)aminocaprillic acid [sic] 367 192 N-10-(2-hydroxy-5-nitroanilino)decanoic acid 368 193 4-(4-(2-chloronicotinoyl)aminophenyl)butyric acid
- and a salt of any of the foregoing.
A method for preparing a composition, said method comprising mixing:
- (A) at least one active agent;
- (B) at least one compound as defined in claim 31;
- and
- (C) optionally, a dosing vehicle.
1 more element
Dependencies are inferred from the claim text.