Back to results
US 2002/0119492 A1Published application
Protein design automation for designing protein libraries with altered immunogenicity
OwnerArthur J. Chirino, Bassil I. Dahiyatinventors
Life of this patent
Estimating the term…
Abstract
The present invention relates to the use of a variety of computational methods for modulating the immunogenicity of proteins by identifying and then altering potential amino acid sequences that elicit an immune response in a host organism. In particular, proteins will be screened for MHC binding sequences, T cell epitopes and B cell epitopes.
Claims18
A method for modulating the immunogenicity of a target protein, said method comprising:
- a) inputting a protein backbone structure with variable residue positions of a target protein into a computer;
- b) computationally generating a set of primary variant amino acid sequences;
- and,
- c) applying a computational immunogenicity filter against said set to identify at least one candidate variant protein.
1 more element
A method for modulating the immunogenicity of a target protein, said method comprising:
- a) inputting a protein backbone structure with variable residue positions of a target protein into a computer;
- b) applying a computational immunogenicity filter to identify at least one candidate variant protein;
- d) computationally analyzing said variant protein for maintenance of native fold and stability;
- nd
- d) generating a set of primary variant amino acid sequences.
2 more elements
Dependencies are inferred from the claim text.