Loading patent…
OwnerLothar Koch, Willem Janssens +3inventors
InventorsLOTHAR KOCH, WILLEM JANSSENS, JACQUES VAN GEEL, FREDDY DEZEURE, DANNY VANSTRAELEN
Estimating the term…
This invention relates to an ex-corpore method of treating human blood cells incorporating tumour cells particularly in the frame of High-Dose Chemotherapy and/or Total Body Irradiation According to the invention, a) carriers selective for specific tumour cells are conjugated to radionuclides which emit short range alpha particles with high linear energy transfer, forming a radioimmunoconjugate, b) a filtration/separation step is performed on the radioimmunoconjugate ensuring the removal of non-conjugated radionuclides, c) stem cells extracted from said blood and/or bone marrow, extracted from a patient for autologous transplant, are mixed ex-corpore with said conjugated radionuclides, d) after an incubation period a purging of the blood cells and/or bone marrow is performed.
An ex-corpore method of treating human blood cells incorporating tumour cells, in particular in the frame of High Dose Chemotherapy and/or Total Body Irradiation, characterized by the following steps:
A method according to any one of the preceding claims, characterized in that chemical ligands, e.g. chelates, are conjugated to the carriers in order to load the radionuclides.
Dependencies are inferred from the claim text.