Human stem cell antigen 2
OwnerJian Ni, Guo-Liang Yu +2inventors
InventorsJian Ni, Guo-Liang Yu, Reiner L. Gentz, Jeannine D. Gocayne
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Abstract
A human stem cell antigen 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating thymocyte maturation and differentiation, protecting neuronal cells, preventing rejection during organ transplantation, treating PNH, Alzheimer's Disease and inflammation is disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
Claims42
An isolated polynucleotide comprising a polynucleotide having at least 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide comprising amino acid 1 to 82 of SEQ ID NO:2;
- and
- (b) the complement of (a).
An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding the same mature polypeptide encoded by the human cDNA in ATCC Deposit No. 97301;
- and
- (b) the complement of (a).
An isolated polypeptide comprising:
- a mature polypeptide encoded by a polynucleotide which is at least 95% identical to the human cDNA contained in ATCC Deposit No. 97301.
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) DNA having a sequence of at least 15 consecutive bases, which sequence is at least 95% complementary to a member selected from the group consisting of:
- (i) DNA having at least 15 consecutive bases from nucleotide 1 to nucleotide 1157 of SEQ ID NO:1;
- (ii) DNA complementary to (i);
- and
- (b) RNA corresponding to the DNA of (a).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) DNA having a sequence of at least 15 consecutive bases, which sequence is at least 95% complementary to a member selected from the group consisting of:
- (i) DNA having at least 15 consecutive bases from the portion of the cDNA of ATCC Deposit No. 97301 which encodes for hSca-2;
- (ii) DNA complementary to (i);
- and
- (b) RNA corresponding to the DNA of (a).
Dependencies are inferred from the claim text.