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US 2002/0119470 A1Published application
Magnetic bead-based array for genetic detection
OwnerMichael I. Nerenberg, Geoffrey C. Landis +5inventors
InventorsMichael I. Nerenberg, Geoffrey C. Landis, Lorelei P. Westin, James P. O'Connell, Ling Wang, Ray R. Radtkey, Lana L. Feng
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Abstract
This invention provides a bead array counter system that combines strand displacement amplification with magnetoresistive micro sensor chips and magnetic beads. The system allows for detection of target nucleic acids in highly dilute samples. The system further provides a means to detect specific nucleic acid sequences comprising SNPs and STRs.
Claims9
A device for detecting a target molecule in a sample solution comprising:
- magnetic beads having in contact therewith polynucleotides capable of participating in an anchored strand displacement amplification reaction;
- a flow cell having channels for receiving a flowable medium, said flow cell further having at least one micro sensor comprising sensor pads and electrodes associated with each sensor pad.
A device for detecting a target molecule in a sample solution comprising:
- magnetic beads having in contact therewith polynucleotide probess capable of hybridizing to a target nucleic acid sequence;
- a flow cell having channels for receiving a flowable medium, said flow cell further having at least one micro sensor comprising sensor pads, said pads further having in contact therewith polynucleotide probes cabable of participating in an anchored strand displacement amplification reaction.
Dependencies are inferred from the claim text.