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OwnerDeborah J. Phippard, Geetha Vasanthakamur +2inventors
InventorsDeborah J. Phippard, Geetha Vasanthakamur, Stanton Dotson, Xiao-Jun Ma
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This invention relates to nucleic acids derived from osteoarthritis (OA) tissue as well as compounds and compositions made using these nucleic acids. A variety of nucleic acid and polypeptide compounds and compositions are described and specifically disclosed. The nucleic acids or polypeptides may be contained within vectors or host cells and then used to produce agents such as nucleic acids, polypeptides, fragments of polypeptides, antibodies, and variants of each. These molecules can be used to diagnose or treat osteoarthritis, or to analyze the disease-modifying activity of OA drugs. Cells containing one or more nucleic acids or polypeptides of the invention can also be used as targets in high-throughput screening methods, particularly in screening for compounds designed to identify compositions affecting osteoarthritis.
A nucleic acid having a nucleotide sequence selected from the group consisting of SEQ NO:
A substantially-purified nucleic acid having at least one 10 nucleotide region substantially identical to a sequence identified in Table 1.
A method of identifying a biologically active compound or composition comprising contacting the compound or composition with a sample comprising a protein, polypeptide, or fragment as claimed in 13, and comparing the interaction between the compound or composition and the protein, polypeptide, or fragment with a control.
A computer-readable medium having recorded thereon the sequence information of one or more of SEQ NO:
A substantially-purified nucleic acid molecule which comprises a nucleic acid sequence that is identical to at least 10 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A substantially-purified nucleic acid molecule which comprises a nucleic acid sequence that is identical to at least 50 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A substantially-purified nucleic acid molecule which comprises a nucleic acid sequence that is identical to at least 100 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
An antibody of claim that is detectably-labeled.
A process for diagnosis or prognosis of osteoarthritis a mammal from the expression of mRNA or cDNA that is identical to at least 20 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
A method of isolating a nucleic acid that is identical to at least 20 nucleotides of a nucleotide sequence selected from the group consisting of SEQ NO:
Dependencies are inferred from the claim text.