Ionic chitosan -iodine complexes : antiseptic hydrogels and wound healing promoters
AssigneePharma C and D, Limited
InventorEmadEldin M. Hassan
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Abstract
This invention describes non-staining, pharmaceutically useful compositions of ionic complexes made between the cationic polymer chitosan or its derivatives and the small anionic iodine-iodide complex (ICIC's). Unlike previously disclosed ion transfer chitosan iodine complexes, ICIC's were found to possess dramatically higher viscosity than those of each ingredient separately, and instantly form a gel structure that is easily dispersible upon shaking. In addition to their antiseptic power, ICIC's showed better skin biocompatibility than povidone iodine and effectively promoted wound healing.
Claims16
A solution comprising an ionic chitosan iodine complex, said solution consisting essentially of:
- a. a cationic polymer comprising chitosan or a derivative thereof;
- b. an aqueous vehicle;
- c. elemental iodine;
- and
- d. an iodide source.
A method for making an iodine chitosan complex, said method comprising the steps of:
- a. dissolving chitosan or a derivative thereof in a portion of an aqueous vehicle to maintain or acquire positive charge;
- b. dissolving iodine and an iodide source in a second portion of aqueous vehicle to maintain or acquire a negative charge;
- and
- c. mixing the two portions of aqueous vehicle to form a homogeneous composition.
Dependencies are inferred from the claim text.