Laboratory scale milling process
AssigneePharmacia & Upjohn Company
InventorRoyal J. Haskell
Life of this patent
Estimating the term…
Abstract
There is provided a process for reducing particle size of a drug, the process comprising (a) a step of dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension; (b) a step of bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension; (c) a step of magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 μm; and (d) a step of separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.
Claims55
A process for reducing particle size of a drug, the process comprising
- (a) dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension;
- (b) bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension;
- (c) magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 μm;
- and
- (d) separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.
A process for reducing particle size of a drug of low water solubility, the process comprising
- (a) dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension;
- (b) bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension;
- (c) magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 μm;
- and
- (d) separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.
Dependencies are inferred from the claim text.