Process and system for controlled-release drug delivery
OwnerStephen Craig Dyar, Mebrahtu Fessehaie +4inventors
InventorsStephen Craig Dyar, Mebrahtu Fessehaie, Isaac Ghebre-Sellassie, Monzer Michael Mayassi, Matthew J. Mollan JR., Haimonot Woldegaber
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Abstract
A controlled-release dosage form for a pharmaceutically-active agent comprises a core, in which the agent is dispersed, surrounded by a diffusion-limiting sleeve. The agent is released at a zero-order or approximately linear rate because the release rate of the agent will be governed entirely by erosion from exposed core surfaces; the surface area of which does not change substantially during the release process. Such a product may be made by co-extruding the core and sleeve material and slicing the extrudate.
Claims24
Pharmaceutical dosage form comprising a central core including a pharmaceutical agent in a controlled-release composition, said core having two exposed opposite end surfaces and a peripheral surface at an outer edge of said core extending between said two opposed end surfaces, said peripheral edge surrounded by a diffusion-limiting sleeve, wherein said sleeve limits the diffusion of fluids into said core.
Method of making a pharmaceutical dosage form comprising coextruding an indefinite length of a central core including a pharmaceutical agent disposed in a controlled-release composition, surrounded by a diffusion-limiting composition, and slicing said co-extrudate across the longitudinal axis thereof.
Dependencies are inferred from the claim text.